Chemokine receptors and their interactors in HIV-1 replication: potential therapeutic targets
Chemokine receptors and their interactors in HIV-1 replication: potential therapeutic targets
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DOI：
10.14800/rci.1016
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发表时间：
2015-09
期刊：
影响因子：
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通讯作者：
Chuan Li;Yi-jie Zhang;D. Dupré;Yi‐Qun Kuang
中科院分区：
文献类型：
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作者：
Chuan Li;Yi-jie Zhang;D. Dupré;Yi‐Qun Kuang
趋化因子受体CXCR 4和CCR 5是人类免疫缺陷病毒1型（HIV-1）进入宿主细胞并随后感染所不可或缺的共受体。基于病毒蛋白的抗逆转录病毒疗法已经开发出来，基于HAART方案的HIV/AIDS患者治疗已经取得了显著成就。然而，仍然存在许多问题，清除潜伏的病毒储存库和治愈艾滋病目前是不可能的，预防性疫苗尚未问世。最近，人们对HIV-1的进入有了更多的了解，基于趋化因子受体的靶向病毒进入代表了一个有趣的前景。在这项研究中，我们回顾了HIV-1共受体相互作用蛋白在趋化因子受体信号激活和组装过程中的作用，并提出了关于它们如何调节病毒复制的新结果。
Chemokine receptors CXCR4 and CCR5 are co-receptors indispensable for human immunodeficiency virus type 1 (HIV-1) entry and subsequent infection in host cells. Antiretroviral therapies based on the viral proteins have been developed, and significant achievements have been made in the treatment of HIV/AIDS patients based on the HAART regimens. However, a lot of concerns are still present, the purge of latent viral reservoirs and cure of AIDS are currently impossible, and prophylactic vaccines are not yet available. Most recently, HIV-1 entry has been understood much more and targeting viral entry based on chemokine receptors represents an interesting prospective. In this research highlight, we review the role of HIV-1 co-receptors-interacting proteins during chemokine receptor signal activation and assembly, as well as present new results about how they can regulate the replication of the virus.