Association of the C677T and A1298C polymorphisms in the 5,10 methylenetetrahydrofolate reductase gene in patients with migraine risk
Association of the C677T and A1298C polymorphisms in the 5,10 methylenetetrahydrofolate reductase gene in patients with migraine risk
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DOI：
10.1016/s0169-328x(02)00672-1
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发表时间：
2003-03-17
期刊：
影响因子：
--
通讯作者：
Kilic, G
中科院分区：
文献类型：
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作者：
Kara, I;Sazci, A;Kilic, G
尽管存在争议，但5,10亚甲基四氢叶酸还原酶（MTHFR）活性降低可能使土耳其人易患偏头痛，MTHFR是一种调节同型半胱氨酸代谢的酶。在一项病例对照研究中，我们确定了102例偏头痛患者（有先兆偏头痛23例，无先兆偏头痛70例，紧张性头痛9例）中两种常见MTHFR多态性C677T和A1298C的患病率，并将其与136名健康对照进行了比较。偏头痛人群中MTHFR677的T等位基因频率（33.82%）和MTHFR1298的C等位基因频率（33.82%）显著高于对照组（25.38%和24.26%）。T677T和C1298C基因型是唯一与偏头痛显著相关的基因型（OR=5.702; 95% CI=1.184-27.457； P=0.015）和（OR=8.933; 95% CI=1.953-40.869； P=0.001）。具有C1298C和C677C/C1298C基因型先兆偏头痛的个体与偏头痛风险的相关性甚至比其他个体更显著（OR=14.105; 95% CI=2.417-82.320； P=0.0001）和（OR=10.050; 95% CI=1.580-63.907； P=0.003）。然而，T677T和C1298C基因型的无先兆偏头痛患者表现出相同的易感性（OR=7.444; 95% CI=1.503-36.863）；P = 0.005)。C1298C和C677C/C1298C基因型患者也可能易患紧张性头痛（OR=8.375; 95% CI=0.685-102.458）；P = 0.049)。(C) 2003 Elsevier Science B.V.版权所有
Although controversial, diminished activity of 5,10 methylenetetrahydrofolate reductase (MTHFR), a regulatory enzyme of homocysteine metabolism, may predispose to migraine in Turkish people. In a case-control study, we determined the prevalence of two common MTHFR polymorphisms,C677T and A1298C, in 102 migraine patients (23 migraine with aura, 70 migraine without aura and nine with tension-type headache) and compared it to that of 136 healthy controls. The frequencies of the T allele of MTHFR677 and the C allele of MTHFR1298 were significantly higher in the total migraine population (33.82%, 33.82%) than in controls (25.38% and 24.26%), respectively. The genotypes T677T and C1298C were the only genotypes significantly associated with migraine (OR=5.702; 95% CI=1.184-27.457; P=0.015) and (OR=8.933; 95% CI=1.953-40.869; P=0.001), respectively). Individuals with migraine with aura with C1298C and C677C/C1298C genotypes were even more profoundly associated with migraine risk than others (OR=14.105; 95% CI=2.417-82.320; P=0.0001) and (OR=10.050; 95% CI=1.580-63.907; P=0.003), respectively. However individuals with migraine without aura with T677T and C1298C genotypes showed the same susceptibility (OR=7.444; 95% CI=1.503-36.863); P=0.005). Patients with C1298C and C677C/C1298C genotypes may also predispose to tension-type headache (OR=8.375; 95% CI=0.685-102.458); P=0.049). (C) 2003 Elsevier Science B.V. All rights reserved.