Elevated antigen-specific Th2 type response is associated with the poor prognosis of hand, foot and mouth disease
Elevated antigen-specific Th2 type response is associated with the poor prognosis of hand, foot and mouth disease
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抗原特异性Th2型反应升高与手足口病预后不良相关
DOI：
10.1016/j.virusres.2013.07.009
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发表时间：
2013-10-01
期刊：
影响因子：
5
通讯作者：
Leng, Qibin
中科院分区：
文献类型：
--
作者：
Wei, Ruicheng;Xu, Lijuan;Leng, Qibin
严重手足口病的免疫发病机制仍不清楚。这项研究表明，手足口病患者的肠道病毒71（EV 71）表位特异性CD 4 + T细胞反应偏向Th 2细胞因子谱。在体外抗原刺激后，CD 4 T细胞中IL-4表达水平较高的患者往往有更长时间的高热和更长的疾病持续时间。因此，EV 71表位特异性Th 2型应答的增加可能预示着某些HFMD患者的预后不良。(C)2013 Elsevier B. V.保留所有权利。
The immunopathogenesis of severe hand, foot and mouth disease (HFMD) remains elusive. This study revealed that enterovirus 71 (EV71) epitope-specific CD4+ T cell responses of HFMD patients were skewed toward a Th2 cytokine profile. Patients that demonstrated higher levels of IL-4 expression in their CD4 T cells following antigen stimulation in vitro tended to have a more prolonged period of high fevers and a longer duration of illness. Thus, an increase of EV71 epitope-specific Th2 type response may portend the poor prognosis for some HFMD patients. (C) 2013 Elsevier B.V. All rights reserved.