Effect of age on the renin-angiotensin-aldosterone system in normal subjects: simultaneous measurement of active and inactive renin, renin substrate, and aldosterone in plasma.
Effect of age on the renin-angiotensin-aldosterone system in normal subjects: simultaneous measurement of active and inactive renin, renin substrate, and aldosterone in plasma.
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年龄对正常受试者肾素-血管紧张素-醛固酮系统的影响：同时测量血浆中活性和非活性肾素、肾素底物和醛固酮。
DOI：
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发表时间：
1986
影响因子：
5.8
通讯作者：
K. Yoshinaga
中科院分区：
文献类型：
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作者：
Kazuo Tzunoda;K. Abe;T. Goto;M. Yasujima;M. Sato;K. Omata;M. Seino;K. Yoshinaga
为探讨增龄对肾素-血管紧张素-醛固酮系统的影响，测定了60例18~84岁正常人血浆肾素底物浓度(PRSC)、血浆总肾素浓度(TRC)、活性肾素浓度(ARC)和非活性肾素浓度(IRC)、血浆肾素活性浓度(PRA)和血浆醛固酮浓度(PAC)。PRSC是通过添加过量的人肾肾素来测量的。加入绵羊肾素底物测定胰酶激活后的ARC和TRC，用TRC减去ARC计算IRC。活性肾素比值计算如下：ARC/TRC×100%。用放射免疫法测定PRA和PAC。PRSC、TRC、IRC和PRA/PAC比值随增龄变化不明显。ARC和活性肾素比值均随增龄而显著下降(r=0.46，P<0.01；r=0.54，P<0.01)。PRA和PAC也有随增龄而降低的趋势(r=0.35，P<0.01；r=0.59，P<0.01)。肾素活性与血管紧张度呈显著正相关(r=0.72，P<0.001)。PRA与PAC也呈正相关。总而言之，PRA的年龄相关性下降不是由于PRSC的变化，而主要是由于ARC的下降。非活性肾素转化为活性肾素的减少可能是老年人ARC减少的部分原因。
To investigate the effect of aging on the renin-angiotensin-aldosterone system, plasma renin substrate concentrations (PRSC); plasma total, active, and inactive renin concentrations (TRC, ARC, and IRC); PRA; and plasma aldosterone concentrations (PAC) were measured simultaneously in 60 normal subjects, 18-84 yr old. PRSC was measured by the addition of excess human renal renin. ARC and TRC after trypsin activation were measured by adding sheep renin substrate; IRC was calculated by subtracting ARC from TRC. The active renin ratio was calculated as follows: ARC/TRC X 100%. PRA and PAC were measured by RIA. There were no significant changes in PRSC, TRC, IRC, and PRA to PAC ratio with aging. Both ARC and active renin ratio fell significantly with aging (r = 0.46 and P less than 0.01; and r = 0.54 and P less than 0.01, respectively). PRA and PAC also tended to decrease with aging (r = 0.35 and P less than 0.01; and r = 0.59 and P less than 0.01, respectively). A significant positive correlation was found between PRA and ARC (r = 0.72; P less than 0.001). PRA was also correlated with PAC. In conclusion, the age-related decrease in PRA is not due to the change in PRSC, but is mainly due to the fall in ARC. Decreased conversion of inactive to active renin might be responsible in part for the reduced ARC in the elderly.
肾素原和其他大分子量形式的肾素。
影响因子：
20.3
作者：
Sealey,JE;Atlas,SA;Laragh,JH
通讯作者：
Laragh,JH