Some epidemiological aspects of "travellers' diarrhoea" in Lebanon.
Some epidemiological aspects of "travellers' diarrhoea" in Lebanon.
复制标题
黎巴嫩“旅行者腹泻”的一些流行病学方面。
DOI：
10.1080/1061186x.2021.1904249
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发表时间：
1960
期刊：
影响因子：
--
通讯作者：
G. Haneveld
中科院分区：
文献类型：
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作者：
G. Haneveld
消化性溃疡病（PUD）是一种常见的疾病，是由酸和胃蛋白酶引起的，导致十二指肠和胃粘膜病变。PUD的发病机制是多方面的，其涉及保护性因素（如胰高血糖素、血流和细胞更新）与侵袭性因素（如酗酒、吸烟、幽门螺杆菌结肠化和使用非甾体抗炎药）之间的不平衡。标准的口服治疗是公认的;然而，几个问题可能会降低这种治疗的成功率，例如药物在胃环境中的降解，口服生物利用度低，以及缺乏靶向部位的载体化。通过这种方式，使用策略来提高这些常规药物的有效性变得有趣。目前，正在探索使用药物递送系统作为改善药物治疗局限性的一种选择，例如抗微生物剂耐药性、低生物利用度、酸性环境中的分子降解以及作用部位的药物浓度低。本文提供了一个审查的口服给药系统，以改善PUD的治疗。
Peptic ulcer disease (PUD) is a common condition that is induced by acid and pepsin causing lesions in the mucosa of the duodenum and stomach. The pathogenesis of PUD is a many-sided scenario, which involves an imbalance between protective factors, such as prostaglandins, blood flow, and cell renewal, and aggressive ones, like alcohol abuse, smoking,Helicobacter pyloricolonisation, and the use of non-steroidal anti-inflammatory drugs. The standard oral treatment is well established; however, several problems can decrease the success of this therapy, such as drug degradation in the gastric environment, low oral bioavailability, and lack of vectorisation to the target site. In this way, the use of strategies to improve the effectiveness of these conventional drugs becomes interesting. Currently, the use of drug delivery systems is being explored as an option to improve the drug therapy limitations, such as antimicrobial resistance, low bioavailability, molecule degradation in an acid environment, and low concentration of the drug at the site of action. This article provides a review of oral drug delivery systems looking for improving the treatment of PUD.