Advances of circular RNAs in carcinoma
Advances of circular RNAs in carcinoma
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环状RNA在癌症中的研究进展
DOI：
10.1016/j.biopha.2018.07.164
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发表时间：
2018
影响因子：
7.5
通讯作者：
Chen Yu
中科院分区：
文献类型：
--
作者：
Chen Yu
环状RNA（CircRNA）是一类具有单链封闭结构的非编码RNA。高通量测序技术的快速发展使得circRNA在转录组中广泛存在。此外，越来越多的研究已经确定了circRNA与不同癌症之间的相关性。此外，大多数circRNA在各种癌症中失调，并且其中一些已被报道在肿瘤的发生和发展中至关重要。例如，ciRS-7在肿瘤促进中起作用，而circ-ITCH充当肿瘤抑制剂。本文综述了circRNA与肿瘤关系的最新研究进展，并展望了circRNA在肿瘤研究中的作用和未来的挑战。
Circular RNAs (circRNAs) are a type of non-coding RNAs with single-stranded closed structure. The rapid development of high-throughput sequencing technology has allowed for the widespread presence of circRNAs in transcriptomes. Moreover, increasing studies have identified a correlation between circRNAs and different cancers. In addition, most circRNAs are dysregulated in various cancers, and some of them have been reported be vital in the occurrence and development of tumors. For example, ciRS-7 plays a role in tumor promotion and circ-ITCH acts as a tumor suppressor. This review summarizes the latest progressions in the field regarding the functions of circRNAs in relation with cancers, and anticipates the emerging roles of circRNAs and future challenges in cancer research.