Trends in estradiol during critical illness are associated with mortality independent of admission estradiol.
Trends in estradiol during critical illness are associated with mortality independent of admission estradiol.
复制标题
危害疾病期间雌二醇的趋势与死亡率无关雌二醇。
DOI：
10.1016/j.jamcollsurg.2010.12.017
复制
发表时间：
2011-04
影响因子：
5.2
通讯作者：
May, Addison K.
中科院分区：
文献类型：
--
作者：
Kauffmann, Rondi M.;Norris, Patrick R.;Jenkins, Judith M.;Dupont, William D.;Torres, Renee E.;Blume, Jeffrey D.;Dossett, Lesly A.;Hranjec, Tjasa;Sawyer, Robert G.;May, Addison K.
We have previously demonstrated that elevated serum estradiol (E2) upon ICU admission is associated with death in the critically ill, regardless of gender. However, little is known about how changes in initial E2 during the course of care might signal increasing patient acuity or risk of death. Changes from baseline serum E2 during the course of critical illness are more strongly associated with mortality than a single admission E2 level. A prospective cohort of 1408 critically ill or injured non-pregnant, adult patients requiring ICU care for ≥ 48 hours with admission and subsequent E2 levels was studied. Demographics, illness severity, and E2 levels were examined and the probability of mortality was modeled with multivariate logistic regression. Changes in E2 were examined by both ANOVA and logistic regression. Overall mortality was 14.1% (95% confidence interval (CI) 12.3%–16%). Both admission and subsequent E2 levels were independently associated with mortality [admission estradiol odds ratio 1.1 (CI 1.0–1.2); repeat estradiol odds ratio 1.3 (CI1.2–1.4)], with subsequent values being stronger. Changes in E2 were independently associated with mortality [odds ratio 1.1 (CI 1.0–1.16)] and improved regression model performance. The regression model produced an area under the ROC curve of 0.80 (CI 0.77–0.83). While high admission levels of E2 are associated with mortality, changes from baseline E2 in critically ill or injured adults are independently associated with mortality. Future studies of E2 dynamics may yield new indicators of patient acuity and illuminate underlying mechanisms for targeted therapy.
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DOI：
10.1097/01.ta.0000051939.95039.e6
发表时间：
2003-03-01
影响因子：
--
作者：
George, RL;McGwin, G;Rue, LW
通讯作者：
Rue, LW
影响因子：
3.1
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Chaudry, IH
DOI：
10.1097/00005373-197403000-00001
发表时间：
1974-01-01
影响因子：
--
作者：
BAKER, SP;ONEILL, B;LONG, WB
通讯作者：
LONG, WB
影响因子：
--
作者：
Romo, H;Amaral, ACKB;Vincent, JL
通讯作者：
Vincent, JL
DOI：
10.1097/00005373-200005000-00019
发表时间：
2000-05-01
影响因子：
--
作者：
Oberholzer, A;Keel, M;Ertel, W
通讯作者：
Ertel, W