Increased ski expression levels are associated with a higher risk and poor prognosis in patients with gastrointestinal stromal tumors
Increased ski expression levels are associated with a higher risk and poor prognosis in patients with gastrointestinal stromal tumors
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Ski表达水平升高与胃肠道间质瘤患者的较高风险和不良预后相关
DOI：
10.3892/ol.2020.11280
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发表时间：
2020-01
期刊：
影响因子：
2.9
通讯作者：
Yuan‑Guo Zhou
中科院分区：
文献类型：
--
作者：
Qiu‑Shi Wang;Yu Zhai;Ping Li;Hua‑Liang Xiao;Yuan‑Guo Zhou
胃肠道间质瘤（GIST）是最常见的胃肠道原发性间叶肿瘤，30%的GIST具有较高的复发或转移风险。国家综合癌症网络目前的风险分类标准是基于肿瘤大小，有丝分裂活性和定位。研究与临床风险相关的其他生物标志物可能有助于GIST的诊断，并改善患者预后的预测。在本研究中，使用癌蛋白ski的表达水平作为GIST的预后预测的价值进行了调查。结果表明，高ski表达水平与高风险和复发率相关，并表明中位无病生存期预后不良。总体而言，本研究表明，ski表达水平可能作为一个预测临床风险和预后的GIST患者。
Gastrointestinal stromal tumors (GISTs) are the most commonly diagnosed primary mesenchymal tumors of the gastrointestinal tract and 30% of GISTs are associated with a high recurrence risk or metastasis. The current risk classification criteria of the National Comprehensive Cancer Network are based on tumor size, mitotic activity and localization. Investigating additional biomarkers associated with clinical risk may aid in the diagnosis of GIST and improves prediction of patient prognosis. In the present study, the value of using the expression levels of the oncoprotein ski as a prognostic predictor for GISTs was investigated. The results demonstrated that high ski expression levels were correlated with high risk and recurrence rates and indicated poor prognosis regarding median disease-free survival. Overall, the present study suggests that ski expression levels may serve as a predictor for clinical risk and prognosis of patients with GISTs.
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影响因子：
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作者：
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