Chlorite dismutases, DyPs, and EfeB: 3 microbial heme enzyme families comprise the CDE structural superfamily.
Chlorite dismutases, DyPs, and EfeB: 3 microbial heme enzyme families comprise the CDE structural superfamily.
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DOI：
10.1016/j.jmb.2011.02.047
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发表时间：
2011-05-06
影响因子：
5.6
通讯作者：
DuBois JL
中科院分区：
文献类型：
--
作者：
Goblirsch B;Kurker RC;Streit BR;Wilmot CM;DuBois JL
血红素蛋白是极其多样、广泛和通用的生物催化剂、传感器和分子转运体。血红素蛋白的α-歧化酶家族之所以得名，是因为第一个分离出的成员能够对人为ClO 2-进行解毒，这一功能被认为是在过去几十年才进化出来的。家族成员已经在15个细菌和古细菌属中发现，这表明了古老的根源。一个结构和序列为基础的检查家庭，其中的关键序列和结构基序被确定，并提出了家庭蛋白质的可能功能。此外，新发现的结构同源性与另外两个大型、古老和功能神秘的蛋白质家族有着明确的联系。我们建议将它们统称为CDE血红素蛋白超家族。
Heme proteins are extremely diverse, widespread, and versatile biocatalysts, sensors, and molecular transporters. The chlorite dismutase family of hemoproteins received its name due to the ability of the first-isolated members to detoxify anthropogenic ClO2−, a function believed to have evolved only in the last few decades. Family members have since been found in fifteen bacterial and archaeal genera, suggesting ancient roots. A structure- and sequence-based examination of the family is presented, in which key sequence and structural motifs are identified and possible functions for family proteins are proposed. Newly identified structural homologies moreover demonstrate clear connections to two other large, ancient, and functionally mysterious protein families. We propose calling them collectively the CDE superfamily of heme proteins.
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作者：
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DOI：
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发表时间：
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期刊：
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发表时间：
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