Borrelidin is an angiogenesis inhibitor; disruption of angiogenic capillary vessels in a rat aorta matrix culture model.
Borrelidin is an angiogenesis inhibitor; disruption of angiogenic capillary vessels in a rat aorta matrix culture model.
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DOI：
10.7164/antibiotics.50.671
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发表时间：
1997-08
期刊：
影响因子：
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通讯作者：
T. Wakabayashi;Rena Kageyama;N. Naruse;Naoko Tsukahara;Y. Funahashi;K. Kitoh;Yoshio Watanabe
中科院分区：
文献类型：
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作者：
T. Wakabayashi;Rena Kageyama;N. Naruse;Naoko Tsukahara;Y. Funahashi;K. Kitoh;Yoshio Watanabe
疏螺旋体素是一种来自罗氏链霉菌的抗生素，在体外形成毛细血管的大鼠主动脉基质培养模型中被发现是一种血管生成抑制剂。疏螺旋体素以0.8 nM的50%抑制浓度值强烈抑制毛细管形成，并且当在管形成成熟后添加时，在24小时内减少毛细管的数量。疏螺旋体素显着破坏毛细血管以剂量依赖性的方式，通过诱导细胞凋亡的管形成细胞。
Borrelidin, an antibiotic from Streptomyces rochei, was found to be an angiogenesis inhibitor in a rat aorta matrix culture model which forms capillary vessels in vitro. Borrelidin strongly inhibited capillary tube formation with a 50%-inhibitory concentration value of 0.8 nM, and decreased the number of capillary tubes within 24 hours when added after maturation of tube formation. Borrelidin remarkably disrupted capillary tubes in a dose-dependent manner, by inducing apoptosis of the tube-forming cells.