Functional compartmentalization of the nucleus.
Functional compartmentalization of the nucleus.
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DOI：
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发表时间：
1996-08
影响因子：
4
通讯作者：
J. Strouboulis;A. Wolffe
中科院分区：
文献类型：
--
作者：
J. Strouboulis;A. Wolffe
细胞生物学和分子遗传学的最新应用已经建立了核组织的图像，其中参与转录，RNA加工和复制的分子机器组装具有定义的功能特性的形态学上不同的核细胞器。这些观察结果表明，细胞核内发生的各种代谢活动具有非常高的结构组织水平。我们讨论了可能存在的新的监管功能固有的核架构本身。
Recent applications of cell biology and molecular genetics have built an image of nuclear organization in which the molecular machines involved in transcription, RNA processing and replication assemble morphologically distinct nuclear organelles with defined functional properties. These observations indicate a very high level of structural organization for the various metabolic activities occurring within the nucleus. We discuss the possible existence of novel regulatory functions inherent to nuclear architecture itself.