Association of peripheral neuropathy with circulating advanced glycation end products, soluble receptor for advanced glycation end products and other risk factors in patients with type 2 diabetes
Association of peripheral neuropathy with circulating advanced glycation end products, soluble receptor for advanced glycation end products and other risk factors in patients with type 2 diabetes
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DOI：
10.1002/dmrr.2529
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发表时间：
2014-11-01
影响因子：
8
通讯作者：
Bourron, O.
中科院分区：
文献类型：
--
作者：
Aubert, C. E.;Michel, P. -L.;Bourron, O.
背景：糖尿病周围神经病变的发病机制尚不清楚，非酶糖氧化是其中一个机制。本研究的目的是评估糖尿病周围神经病变与糖氧化的各自关系，并与其他已确定的危险因素进行比较，2型糖尿病患者。方法纳入198例血管并发症高危的2型糖尿病患者。测定了三种晚期糖基化终产物（羧甲基赖氨酸、甲基乙二醛氢咪唑酮-1、戊苷）及其可溶性受体（sRAGE）的循环浓度。周围神经病变通过神经病变残疾评分和单丝试验进行评估，并定义为单丝试验异常和/或神经病变残疾评分6。多因素回归分析调整了神经病变的潜在混杂因素：年龄、性别、糖尿病病程、当前吸烟、收缩压、腰围、身高、外周动脉闭塞疾病、糖化血红蛋白、估计肾小球滤过率和血脂。结果周围神经病变发生率为20.7%。sRAGE和羧甲基赖氨酸与周围神经病变的存在独立且正相关。周围神经病变与甲基乙二醛-氢咪唑酮-1或戊苷之间无显著关联。腰围、身高和周围动脉闭塞性疾病与周围神经病变独立相关。结论scarboxymethyllysine和sRAGE与2型糖尿病周围神经病变独立相关。虽然结论受到缺乏健康对照人群的限制，但该研究证实了晚期糖氧化与糖尿病周围神经病变之间的关系，独立于其他危险因素。版权所有：John Wiley & Sons， Ltd。
BackgroundThe pathogenesis of diabetic peripheral neuropathy remains uncertain and nonenzymatic glycoxidation is one of the contributing mechanisms. The aim of this study was to assess the respective relationship of diabetic peripheral neuropathy with glycoxidation, compared with other identified risk factors, in patients with type 2 diabetes.MethodsWe included 198 patients with type 2 diabetes and high risk for vascular complications. Circulating concentrations of three advanced glycation end products (carboxymethyllysine, methyl-glyoxal-hydroimidazolone-1, pentosidine) and of their soluble receptor (sRAGE) were measured. Peripheral neuropathy was assessed by the neuropathy disability score and by the monofilament test and defined as either an abnormal monofilament test and/or a neuropathy disability score 6. Multivariate regression analyses were performed adjusting for potential confounding factors for neuropathy: age, gender, diabetes duration, current smoking, systolic blood pressure, waist circumference, height, peripheral arterial occlusive disease, glycated haemoglobin, estimated glomerular filtration rate and lipid profile.ResultsPrevalence of peripheral neuropathy was 20.7%. sRAGE and carboxymethyllysine were independently and positively associated with the presence of peripheral neuropathy. No significant association was found between peripheral neuropathy and methyl-glyoxal-hydroimidazolone-1 or pentosidine. Waist circumference, height and peripheral arterial occlusive disease were independently associated with peripheral neuropathy.ConclusionsCarboxymethyllysine and sRAGE were independently associated with peripheral neuropathy in patients with type 2 diabetes. Although the conclusions are limited by the absence of a healthy control population, this study confirms the relationship between advanced glycoxidation and diabetic peripheral neuropathy, independently of other risk factors. Copyright (c) 2014 John Wiley & Sons, Ltd.