Effects of distraction on muscle length: mechanisms involved in sarcomerogenesis.
Effects of distraction on muscle length: mechanisms involved in sarcomerogenesis.
复制标题
注意力分散对肌肉长度的影响：参与肌瘤形成的机制。
DOI：
10.1097/00003086-200210001-00016
复制
发表时间：
2002
影响因子：
4.2
通讯作者：
Green,Stuart
中科院分区：
文献类型：
--
作者：
Caiozzo,VincentJ;Utkan,Ali;Chou,Richard;Khalafi,Afshin;Chandra,Heena;Baker,Michael;Rourke,Bryan;Adams,Greg;Baldwin,Ken;Green,Stuart
尽管人们对了解由于阻力训练而发生的调节径向生长的机制非常感兴趣，但对由于被动拉伸而发生的骨骼肌纵向生长的研究却少得多。目前的作者提供了一个简短的概述有关的关键问题，发生在牵张成骨过程中的骨骼肌的纵向生长。具体而言，五个关键问题是解决：（1）在牵引过程中的肌角化的模式;（2）肌角化和肌角化和非肌角化基因的表达改变;（3）卫星细胞假说;（4）促有丝分裂因子;（5）研究骨骼肌纵向生长的新方法。围绕负反馈回路的概念进行了讨论。肌肉生物学中最有趣的问题之一是卫星细胞在调节骨骼肌生长中的作用。目前，尚不清楚卫星细胞激活是否是骨骼肌纵向生长的先决条件。基因芯片分析提供了一个自相矛盾的观点，表明牵张成骨导致GADD 45基因上调，与生长停滞和脱氧核糖核酸破坏有关。
Although a great deal of interest has been given to understanding the mechanisms involved in regulating the radial growth that occurs because of resistance training, much less has been given to studying the longitudinal growth of skeletal muscle that occurs because of passive stretch. The current authors provide a brief overview of key issues relevant to the longitudinal growth of skeletal muscle that occurs during distraction osteogenesis. Specifically, five key issues are addressed:(1) the pattern of sarcomerogenesis during distraction;(2) sarcomerogenesis and altered expression of sarcomeric and nonsarcomeric genes;(3) the satellite cell hypothesis;(4) mitogenic factors; and (5) new approaches for studying the longitudinal growth of skeletal muscle. A discussion is provided that revolves around the concept of a negative feedback loop. One of the most interesting issues to be resolved in muscle biology is the role of satellite cells in regulating the growth of skeletal muscle. Currently, it is not known whether satellite cell activation is a prerequisite for the longitudinal growth of skeletal muscle. Gene chip analyses provide a paradoxical view, showing that distraction osteogenesis results in the upregulation of a gene, GADD45, involved with growth arrest and deoxyribonucleic acid destruction.