Survival plots of time-to-event outcomes in clinical trials: good practice and pitfalls
Survival plots of time-to-event outcomes in clinical trials: good practice and pitfalls
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DOI：
10.1016/s0140-6736(02)08594-x
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发表时间：
2002-05-11
期刊：
影响因子：
168.9
通讯作者：
Altman, DG
中科院分区：
文献类型：
--
作者：
Pocock, SJ;Clayton, TC;Altman, DG
至事件发生时间数据的生存曲线是许多临床试验（和队列研究）报告结果的关键组成部分。然而，在生存情节的展示和解读中，往往会出现错误和扭曲。本文旨在强调这些陷阱，并为未来的实践提供建议。研究结果说明了专题的例子，也是基于最近的临床试验出版物在四个主要期刊的调查。具体问题是：图是上升还是下降（我们建议上升），图延长的时间，显示随访的程度，通过包括SE或CIS显示统计不确定性，以及在解释图的形状和治疗差异的时间模式时要谨慎。
Survival plots of time-to-event data are a key component for reporting results of many clinical trials (and cohort studies). However, mistakes and distortions often arise in the display and Interpretation of survival plots. This article aims to highlight such pitfalls and provide recommendations for future practice. Findings are illustrated by topical examples and also based on a survey of recent clinical trial publications In four major journals. Specific issues are: should plots go up or down (we recommend up), how far in time to extend the plot, showing the extent of follow-up, displaying statistical uncertainty by including SEs or CIS, and exercising caution when Interpreting the shape of plots and the time-pattern of treatment difference.