Scanning microwave-induced thermoacoustic tomography: Signal, resolution, and contrast
Scanning microwave-induced thermoacoustic tomography: Signal, resolution, and contrast
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DOI：
10.1118/1.1333409
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发表时间：
2001-01-01
期刊：
影响因子：
3.8
通讯作者：
Wang, LHV
中科院分区：
文献类型：
--
作者：
Ku, G;Wang, LHV
在电磁波谱的微波区探索了扫描热声层析成像技术。利用短微波脉冲在生物组织中热弹性膨胀诱导声波。组织样品的横截面通过样品的线性扫描成像，而聚焦超声换能器检测时间分辨热声信号。基于正常乳腺组织和癌性乳腺组织的微波吸收特性，研究了热声对比对压电信号的响应，并在肿瘤位置的宽电磁频率和深度范围内进行了研究。轴向分辨率与微波脉冲的时间分布和超声换能器的脉冲响应有关。横向分辨率与换能器的数值孔径有关，也与轴向分辨率对应的时间窗内压电信号的频谱有关。利用增益补偿抵消微波衰减，增强图像对比度。(C) 2001年美国医学物理学家协会。
Scanning thermoacoustic tomography was explored in the microwave region of the electromagnetic spectrum. Short microwave pulses were used to induce acoustic waves by thermoelastic expansion in biological tissues. Cross sections of tissue samples were imaged by a linear scan of the samples while a focused ultrasonic transducer detected the time-resolved thermoacoustic signals. Based on the microwave-absorption properties of normal and cancerous breast tissues, the piezoelectric signals in response to the thermoacoustic contrast were investigated over a wide range of electromagnetic frequencies and depths of tumor locations. The axial resolution is related to the temporal profile of the microwave pulses and to the impulse response of the ultrasonic transducer. The lateral resolution is related to the numerical aperture of the ultrasonic transducer as well as to the frequency spectra of the piezoelectric signals in the time window corresponding to the axial resolution. Gain compensation, counteracting the microwave attenuation, was applied to enhance the image contrast. (C) 2001 American Association of Physicists in Medicine.