Changes of heat pain sensitivity during the menstrual cycle in Japanese young adults: a randomized trial
Changes of heat pain sensitivity during the menstrual cycle in Japanese young adults: a randomized trial
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日本年轻人月经周期期间热痛敏感性的变化：一项随机试验
DOI：
10.11154/pain.34.304
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发表时间：
2019
期刊：
影响因子：
--
通讯作者：
Ogino Yuichi
中科院分区：
文献类型：
--
作者：
Kakeda Takahiro;Takani Kei;Takaoka Koichi;Tanaka Noriyoshi;Ogino Yuichi
本研究的目的是比较日本年轻人月经周期卵泡期和黄体期的疼痛敏感性。在这项采用交叉设计的随机对照试验中，15名女性接受了艾德治疗。疼痛阈值（定义为受试者开始感到疼痛时的温度）使用热疼痛刺激器在拇指短屈肌上测量。对于每位受试者，刺激进行10次，在右手和左手之间交替进行。疼痛反应性的评价使用自我确定的热痛阈值，唾液α淀粉酶，情绪评价使用的情绪状态和视觉模拟量表评分的配置文件。经比较分析发现，卵泡期痛阈较黄体期痛阈明显升高，说明月经周期会影响疼痛感觉的严重程度。黄体期疼痛敏感性对伤害性刺激的敏感性高于卵泡期。因此，我们需要进行疼痛管理，注意月经周期。此外，处于生育年龄的年轻女性在月经周期的黄体期应该在疼痛管理方面更具保护性。
The aim of this study was to compare pain sensitivity between the follicular and luteal phases of the menstrual cycle in Japanese young adults. Fifteen females participat ed in this randomized control trial with crossover design. The pain threshold (defined as the temperature when the subject started to feel pain) was measured using a heat pain stimulator on the short flexor muscle of the thumb. For each subject, the stimulus was performed 10 times, alternating between the right and left hand. Pain reactivity was evaluated using a self–identified threshold of heat pain, salivary alpha amylase, emotional evaluation using a profile of mood states and visual analog scale scores. After comparative analysis, we found that pain threshold under the follicular phase was significantly increased compared to that under the luteal phase, indicating that the menstrual cycle would influence the severity of pain perception. Pain sensitivity under the luteal phase is more sensitive to nociceptive stimuli than those under the follicular phase. We therefore need to conduct pain management with paying heed to the menstrual cycle. Additionally, young women in reproductive–age should be more protective in pain management during the luteal phase of their menstrual cycle.