Weight gain associated with increased food intake and low habitual activity levels in male adolescent schizophrenic inpatients treated with olanzapine
Weight gain associated with increased food intake and low habitual activity levels in male adolescent schizophrenic inpatients treated with olanzapine
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DOI：
10.1176/appi.ajp.159.6.1055
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发表时间：
2002-06-01
影响因子：
17.7
通讯作者：
Apter, A
中科院分区：
文献类型：
--
作者：
Gothelf, D;Falk, B;Apter, A
目的：作者研究了奥氮平治疗患者的体重增加机制和能量平衡。方法：在基线和治疗 4 周后测量接受奥氮平治疗的男性精神分裂症青少年住院患者 (N=10) 和 10 名接受氟哌啶醇治疗的匹配患者 (N=10) 的体重指数。对于接受奥氮平治疗的患者，在基线和治疗 4 周后评估热量摄入、静息能量消耗和身体活动（通过加速度测量和心率监测确定）。结果：接受奥氮平治疗的患者体重指数显着增加，但接受氟哌啶醇治疗的患者体重指数没有显着增加。体重指数的增加是由于热量摄入的增加而饮食结构没有改变。奥氮平对静息能量消耗没有显着影响。治疗前后每日能量消耗非常低。结论：奥氮平引起的体重增加与热量摄入的普遍增加有关。
Objective: The authors studied weight gain mechanisms and energy balance in patients treated with olanzapine.Method: The body mass index of male schizophrenic adolescent inpatients treated with olanzapine (N=10) and of 10 matched patients treated with haloperidol (N=10) were measured at baseline and after 4 weeks of treatment. For the patients treated with olanzapine, caloric intake, resting energy expenditure, and physical activity (determined through accelerometry and heart rate monitoring) were assessed at baseline and after 4 weeks of treatment.Results: Body mass index significantly increased in those treated with olanzapine but not in those given haloperidol. The increase in body mass index was due to an increase in caloric intake without change in diet composition. olanzapine had no significant effect on resting energy expenditure. Daily energy expenditure was very low before and after treatment.Conclusions: Olanzapine-induced weight gain is associated with a general increase in caloric intake.