Medial prefrontal cortex infusions of bupivacaine or AP-5 block extinction of amphetamine conditioned place preference
Medial prefrontal cortex infusions of bupivacaine or AP-5 block extinction of amphetamine conditioned place preference
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DOI：
10.1016/j.nlm.2007.08.006
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发表时间：
2008-05-01
影响因子：
2.7
通讯作者：
Packard, Mark G.
中科院分区：
文献类型：
--
作者：
Hsu, Emily;Packard, Mark G.
The present experiments used reversible lesion techniques and intra-mPFC infusions of the n-methyl D-aspartate (NMDA) receptor antagonist D,L-2-amino-5-phosphonovaleric acid (AP-5) to examine the role of the mPFC in extinction of an amphetamine conditioned place preference (CPP). Following initial training and testing for an amphetamine (2 mg/kg) CPP, adult male Long-Evans rats were given extinction trials that were identical to training, except in the absence of peripheral amphetamine injections. Immediately prior to each extinction trial, rats received intra-mPFC infusions of the anesthetic drug bupivacame (0.75% solution/0.5 mu l), AP-5 (1.25, 2.5, 5.0 mu g/0.5 mu l), or saline. Following extinction training, rats were given a second CPP test session. Rats receiving intra-mPFC infusions of saline displayed extinction of CPP behavior. In contrast, intra-mPFC infusions of bupivacame or AP-5 (2.5, 5.0 mu g) blocked CPP extinction. The findings indicate (1) the mPFC mediates extinction of approach behavior to drug-associated environmental contexts, and (2) NMDA receptor blockade within the mPFC is sufficient to block extinction of amphetamine CPP behavior. (C) 2007 Elsevier Inc. All rights reserved.
