Ability of myeloma cells to secrete macrophage inflammatory protein (MIP)-1α and MIP-1β correlates with lytic bone lesions in patients with multiple myeloma
Ability of myeloma cells to secrete macrophage inflammatory protein (MIP)-1α and MIP-1β correlates with lytic bone lesions in patients with multiple myeloma
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DOI：
10.1111/j.1365-2141.2004.04864.x
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发表时间：
2004-04-01
影响因子：
6.5
通讯作者：
Matsumoto, T
中科院分区：
文献类型：
--
作者：
Hashimoto, T;Abe, M;Matsumoto, T
巨噬细胞炎症蛋白 (MIP)-1α 和 MIP-1β 已被确定为多发性骨髓瘤 (MM) 衍生骨吸收因子的候选者。为了验证这些观察结果的临床相关性，我们研究了 MM 细胞分泌这些趋化因子的能力与 MM 骨病变的程度以及 MM 患者的生化骨标志物水平之间的相关性。与具有轻微骨病变的患者相比，多发性骨病变患者表现出较高的 MM 细胞 MIP-1α 和 MIP-1β 分泌，以及尿脱氧吡啶啉 (Dpd) 升高，但血清骨特异性碱性磷酸酶 (BALP) 或骨钙素没有显着升高。 MIP-1α和MIP-1β水平与尿Dpd和血清BALP呈正相关，但与血清骨钙素无关。这些结果为MIP-1α和MIP-1β在溶解性骨病变发展中的因果作用提供了进一步的证据，并表明MM细胞抑制成骨细胞骨形成，导致骨转换不平衡和破坏性骨病变的发展。
Macrophage inflammatory protein (MIP)-1alpha and MIP-1beta have been identified as candidates for multiple myeloma (MM)-derived bone-resorbing factors. To validate the clinical relevance of these observations, we investigated correlations between the ability of MM cells to secrete these chemokines and the extent of MM bone lesions as well as levels of biochemical bone markers in patients with MM. Patients with multiple bone lesions exhibited higher MIP-1alpha and MIP-1beta secretion from MM cells along with elevated urinary deoxypyridinoline (Dpd), without significant elevation of serum bone-specific alkaline phosphatase (BALP) or osteocalcin compared with those with minimal bone lesions. MIP-1alpha and MIP-1beta levels correlated positively with urinary Dpd and serum BALP but not with serum osteocalcin. These results provide further evidence for a causal role of MIP-1alpha and MIP-1beta in the development of lytic bone lesions, and suggest that MM cells suppress osteoblastic bone formation to cause an imbalance of bone turnover and development of destructive bone lesions.