Positive and negative functions of B lymphocytes in tumors.
Positive and negative functions of B lymphocytes in tumors.
复制标题
B淋巴细胞在肿瘤中的正负功能
DOI：
10.18632/oncotarget.10094
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发表时间：
2016-08-23
期刊：
影响因子：
--
通讯作者：
Ren X
中科院分区：
文献类型：
--
作者：
Shen M;Sun Q;Wang J;Pan W;Ren X
越来越多的证据表明，B淋巴细胞在肿瘤免疫中发挥着复杂的功能。一方面，B淋巴细胞可以通过抗体产生、抗原呈递、肿瘤组织相互作用和直接杀伤来抑制肿瘤的发展。另一方面，B淋巴细胞具有促肿瘤功能。被称为调节性B细胞的典型类型的B淋巴细胞被证实减弱肿瘤环境中的免疫应答。在本文中，我们总结了目前对B细胞功能在肿瘤免疫学中的理解，这可能会为潜在的癌症治疗策略提供启示。
Accumulating evidence indicated that B lymphocytes exerted complex functions in tumor immunity. On the one hand, B lymphocytes can inhibit tumor development through antibody generation, antigen presentation, tumor tissue interaction, and direct killing. On the other hand, B lymphocytes have tumor-promoting functions. A typical type of B lymphocytes, termed regulatory B cells, is confirmed to attenuate immune response in a tumor environment. In this paper, we summarize the current understanding of B-cell functions in tumor immunology, which may shed light on potential therapeutic strategies against cancer.