The Role of ITAM- and ITIM-coupled Receptors in Platelet Activation by Collagen
The Role of ITAM- and ITIM-coupled Receptors in Platelet Activation by Collagen
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DOI：
10.1055/s-0037-1616225
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发表时间：
2001-07
影响因子：
6.7
通讯作者：
S. Watson;N. Asazuma;B. Atkinson;O. Berlanga;D. Best;R. Bobe;G. Jarvis;S. Marshall;D. Snell;M. Stafford;D. Tulasne;J. Wilde;P. Wonerow;J. Frampton
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文献类型：
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作者：
S. Watson;N. Asazuma;B. Atkinson;O. Berlanga;D. Best;R. Bobe;G. Jarvis;S. Marshall;D. Snell;M. Stafford;D. Tulasne;J. Wilde;P. Wonerow;J. Frampton
主要的激活诱导胶原受体糖蛋白VI（GPVI）已在过去两年中克隆。是蛋白质IG超家族的成员，与携带ITAM的Fc受体γ链（FcR γ链）组成型相关。GPVI通过涉及Fc、B-和T-淋巴细胞受体所用的几种蛋白质的途径进行信号传导，该途径发生在质膜中的糖脂富集膜结构域（称为GEM）中。对GPVI的反应受PECAM-1（CD 31）和其他可能携带ITIM的受体调节。尽管GPVI具有关键作用，但胶原蛋白和GPVI特异性配体的信号传导事件之间存在重要差异。这可能反映了共受体在对胶原蛋白的反应中的作用。
Summary The major activation-inducing collagen receptor glycoprotein VI (GPVI) has been cloned within the last two years. It is a member of the Ig superfamily of proteins and is constitutively associated with the ITAM-bearing Fc receptor γ-chain (FcR γ-chain). GPVI signals through a pathway that involves several of the proteins used by Fc, B- and T-lymphocyte receptors and which takes place in glycolipid-enriched membrane domains in the plasma membrane known as GEMs. Responses to GPVI are regulated by PECAM-1 (CD31) and possibly other ITIM-bearing receptors. Despite a pivotal role for GPVI, there are important differences between signalling events to collagen and GPVI-specific ligands. This may reflect a role for co-receptors in the response to collagen.