Altered plasma cytokine levels in Alzheimer's disease: Correlation with the disease progression
Altered plasma cytokine levels in Alzheimer's disease: Correlation with the disease progression
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DOI：
10.1016/j.imlet.2007.09.002
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发表时间：
2007-11-30
影响因子：
4.4
通讯作者：
Malaguarnera, L.
中科院分区：
文献类型：
--
作者：
Motta, M.;Imbesi, R.;Malaguarnera, L.
越来越多的证据支持阿尔茨海默病（AD）发病机制中的炎症倾向。在我们以前的研究中，我们观察到高水平的IL-16，IL-18和TGF-β 1 mRNA表达的单核细胞-巨噬细胞的AD患者的外周血。本研究的目的是确定AD患者在疾病的不同阶段的IL-12、IL-16、IL-18和TGF-β 1的血浆水平，并将这些细胞因子的产生与疾病进展相关联。轻度AD患者IL-12、IL-16、IL-18和TGF-β 1水平较高，中度AD患者略低，而重度AD患者与年龄匹配的非痴呆受试者之间没有观察到显著差异。血浆细胞因子水平之间的相关性值依赖于疾病的进展。我们的数据表明，这些炎症分子的血浆水平遵循AD的程度，表明AD的免疫反应性逐渐下降。(c)2007 Elsevier B. V.保留所有权利。
Increasing evidence supports a propensity towards inflammation in Alzheimer's disease (AD) pathogenesis. In our previous studies we observed high levels of IL-16, IL-18 and TGF-beta 1 mRNA expression in monocyte-macrophages of the peripheral blood of AD patients. The aim of this investigation was to determine the plasma levels of IL-12, IL-16, IL-18 and TGF-beta 1 in AD patients at different stages of the disease and to correlate the production of these cytokines with the disease progression. The levels of IL-12, IL-16,IL-18 and TGF-beta 1 resulted higher in AD-mild patients, were slightly lower in AD-moderate patients, whereas no significant difference was observed between AD-severe patients and non-demented age-matched subjects. The correlation values between cytokine plasma levels were dependent on the disease progression. Our data indicate that plasma levels of these inflammatory molecules follow the degree of AD suggesting a gradual decline of immune responsiveness in AD. (c) 2007 Elsevier B.V. All rights reserved.