Osteoinduction of porous bioactive titanium metal
Osteoinduction of porous bioactive titanium metal
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DOI：
10.1016/s0142-9612(03)00551-9
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发表时间：
2004-02-01
期刊：
影响因子：
14
通讯作者：
Nakamura, T
中科院分区：
文献类型：
--
作者：
Fujibayashi, S;Neo, M;Nakamura, T
这是第一次报道钛金属在非骨部位的骨诱导，钛金属一直被认为是一种非生物活性材料。在经过特定的化学和热处理后，多孔生物活性钛诱导骨形成，而不需要额外的成骨细胞或骨诱导剂。将四种类型的钛种植体植入成年比格犬的背部肌肉中，并在3个月和12个月后进行组织学检查。经化学和热处理的钛以及纯钛作为多孔块或纤维网圆柱体植入。仅在12个月后取出的化学和热处理多孔块植入物中发现骨形成。本研究表明，即使是不含钙或磷的不溶性金属，当处理形成适当的宏观结构和微观结构时，也可以是骨诱导材料。这一发现可能阐明骨诱导的本质，并导致划时代的骨组织再生生物材料的出现。(C)2003 Elsevier Ltd.保留所有权利。
This is the first report of bone induction in a non-osseous site by titanium metal, which has long been recognized as a nonbioactive material. After undergoing specific chemical and thermal treatments, porous bioactive titanium induced bone formation without the need of additional osteogenic cells or osteoinductive agents. Four types of titanium implants were implanted in the dorsal muscles of mature beagle dogs, and were examined histologically after periods of 3 and 12 months. Chemically and thermally treated titanium, as well as pure titanium, was implanted either as porous blocks or as fibre mesh cylinders. Bone formation was found only in the chemically and thermally treated porous block implants removed after 12 months. The present study shows that even a non-soluble metal that contains no calcium or phosphorus can be an osteoinductive material when treated to form an appropriate macrostructure and microstructure. This finding may elucidate the nature of osteoinduction, and lead to the advent of epochal osteoinductive biomaterials for tissue regeneration. (C) 2003 Elsevier Ltd. All rights reserved.