Club Cell Secreted Protein CC16: Potential Applications in Prognosis and Therapy for Pulmonary Diseases.
Club Cell Secreted Protein CC16: Potential Applications in Prognosis and Therapy for Pulmonary Diseases.
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俱乐部细胞分泌蛋白CC16：在肺部疾病预后和治疗中的潜在应用
DOI：
10.3390/jcm9124039
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发表时间：
2020-12-14
影响因子：
3.9
通讯作者：
Zhang D
中科院分区：
文献类型：
--
作者：
Almuntashiri S;Zhu Y;Han Y;Wang X;Somanath PR;Zhang D
俱乐部细胞分泌蛋白（CC 16）由SCGB 1A 1基因编码。它也被称为CC 10，分泌珠蛋白或子宫珠蛋白。CC 16是主要由无纤毛支气管上皮细胞分泌的16 kDa同源二聚体蛋白，其可在气道、循环、痰、鼻液和尿液中检测到。CC 16的生物学活性及其途径尚未完全了解，但许多研究表明CC 16具有抗炎和抗氧化作用。人类CC 16基因位于11号染色体p12-q13上，其中存在几个过敏和炎症的调节基因。研究表明，性别，年龄，肥胖，肾功能，昼夜变化和运动等因素调节循环中的CC 16水平。目前的研究表明CC 16不仅可以反映肺部疾病的发病机制，而且可以作为多种肺部疾病的潜在生物标志物和慢性阻塞性肺疾病（COPD）的有希望的治疗。本文就CC 16在肺部疾病中的作用作一综述。
Club cell secretory protein (CC16) is encoded by the SCGB1A1 gene. It is also known as CC10, secretoglobin, or uteroglobin. CC16 is a 16 kDa homodimeric protein secreted primarily by the non-ciliated bronchial epithelial cells, which can be detected in the airways, circulation, sputum, nasal fluid, and urine. The biological activities of CC16 and its pathways have not been completely understood, but many studies suggest that CC16 has anti-inflammatory and anti-oxidative effects. The human CC16 gene is located on chromosome 11, p12-q13, where several regulatory genes of allergy and inflammation exist. Studies reveal that factors such as gender, age, obesity, renal function, diurnal variation, and exercise regulate CC16 levels in circulation. Current findings indicate CC16 not only may reflect the pathogenesis of pulmonary diseases, but also could serve as a potential biomarker in several lung diseases and a promising treatment for chronic obstructive pulmonary disease (COPD). In this review, we summarize our current understanding of CC16 in pulmonary diseases.
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作者：
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DOI：
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发表时间：
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影响因子：
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