Epigenetic clocks reveal a rejuvenation event during embryogenesis followed by aging.
Epigenetic clocks reveal a rejuvenation event during embryogenesis followed by aging.
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表观遗传时钟揭示了胚胎发生过程中的复壮事件，随后是衰老。
DOI：
10.1126/sciadv.abg6082
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发表时间：
2021-06
期刊：
影响因子：
13.6
通讯作者：
Gladyshev VN
中科院分区：
文献类型：
--
作者：
Kerepesi C;Zhang B;Lee SG;Trapp A;Gladyshev VN
表观遗传时钟揭示了胚胎发生后衰老过程中的返老还童事件。细菌系不会老化的观点可以追溯到19世纪奥古斯特·魏斯曼的思想。然而，作为新陈代谢活跃的生殖系，随着时间的推移，它会积累损害和其他变化，即它会老化。为了在相同的年轻状态下开始新的生命，生殖系必须在后代中恢复活力。在这里，我们开发了一种多组织表观遗传学时钟，并将其与其他衰老时钟一起应用于跟踪小鼠和人类产前发育过程中生物年龄的变化。这一分析表明，在胚胎发育的早期阶段，生物年龄(即复壮)显著减少，随后在后期增加。我们进一步发现，多能干细胞即使在广泛传代后也不会老化，而且所检查的表观遗传年龄动态在不同物种之间是保守的。总体而言，这项研究揭示了胚胎发育过程中的一种自然恢复活力的事件，并表明最小生物年龄(归零)标志着生物衰老的开始。
Epigenetic clocks reveal a rejuvenation event during embryogenesis followed by aging. The notion that the germ line does not age goes back to the 19th-century ideas of August Weismann. However, being metabolically active, the germ line accumulates damage and other changes over time, i.e., it ages. For new life to begin in the same young state, the germ line must be rejuvenated in the offspring. Here, we developed a multi-tissue epigenetic clock and applied it, together with other aging clocks, to track changes in biological age during mouse and human prenatal development. This analysis revealed a significant decrease in biological age, i.e., rejuvenation, during early stages of embryogenesis, followed by an increase in later stages. We further found that pluripotent stem cells do not age even after extensive passaging and that the examined epigenetic age dynamics is conserved across species. Overall, this study uncovers a natural rejuvenation event during embryogenesis and suggests that the minimal biological age (ground zero) marks the beginning of organismal aging.
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影响因子：
48
作者：
Kurian, Leo;Sancho-Martinez, Ignacio;Nivet, Emmanuel;Aguirre, Aitor;Moon, Krystal;Pendaries, Caroline;Volle-Challier, Cecile;Bono, Francoise;Herbert, Jean-Marc;Pulecio, Julian;Xia, Yun;Li, Mo;Montserrat, Nuria;Ruiz, Sergio;Dubova, Ilir;Rodriguez, Concepcion;Denli, Ahmet M.;Boscolo, Francesca S.;Thiagarajan, Rathi D.;Gage, Fred H.;Loring, Jeanne F.;Laurent, Louise C.;Izpisua Belmonte, Juan Carlos
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Izpisua Belmonte, Juan Carlos
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影响因子：
16
作者：
Hannum, Gregory;Guinney, Justin;Zhao, Ling;Zhang, Li;Hughes, Guy;Sadda, SriniVas;Klotzle, Brandy;Bibikova, Marina;Fan, Jian-Bing;Gao, Yuan;Deconde, Rob;Chen, Menzies;Rajapakse, Indika;Friend, Stephen;Ideker, Trey;Zhang, Kang
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影响因子：
5.7
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通讯作者：
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影响因子：
4.5
作者：
Fabris F;Magalhães JP;Freitas AA
通讯作者：
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影响因子：
12.3
作者：
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通讯作者：
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