Truly-Biocompatible Gold Catalysis Enables Vivo-Orthogonal Intra-CNS Release of Anxiolytics.
Truly-Biocompatible Gold Catalysis Enables Vivo-Orthogonal Intra-CNS Release of Anxiolytics.
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真正的生物相容性金催化使抗焦虑药能够在体内正交中枢神经系统内释放。
DOI：
10.1002/ange.202111461
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发表时间：
2022
期刊：
影响因子：
--
通讯作者：
Ortega-Liebana MC
中科院分区：
文献类型：
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作者：
Ortega-Liebana MC
金（Au）被公认为是所有金属中耐受性最好的金属，但其催化潜力迄今为止一直受到生物体中普遍存在的硫醇的阻碍。在本文中，我们报告了通过静电负载在共聚物支架的蛋白排斥外层组装超小Au-纳米颗粒来开发真正催化的Au-聚合物复合材料。为了说明新型催化剂的体内相容性，我们展示了它们在发育中的斑马鱼的中枢神经系统（CNS）中释放抗焦虑剂氟西汀的能力，从而影响它们的游泳模式。这种生物正交策略首次通过在动物大脑中直接释放神经活性剂来改变认知活动。
Being recognized as the best‐tolerated of all metals, the catalytic potential of gold (Au) has thus far been hindered by the ubiquitous presence of thiols in organisms. Herein we report the development of a truly‐catalytic Au‐polymer composite by assembling ultrasmall Au‐nanoparticles at the protein‐repelling outer layer of a co‐polymer scaffold via electrostatic loading. Illustrating the in vivo‐compatibility of the novel catalysts, we show their capacity to uncage the anxiolytic agent fluoxetine at the central nervous system (CNS) of developing zebrafish, influencing their swim pattern. This bioorthogonal strategy has enabled ‐for the first time‐ modification of cognitive activity by releasing a neuroactive agent directly in the brain of an animal.