The universal dynamics of tumor growth
The universal dynamics of tumor growth
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DOI：
10.1016/s0006-3495(03)74715-8
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发表时间：
2003-11-01
影响因子：
3.4
通讯作者：
Brú, I
中科院分区：
文献类型：
--
作者：
Brú, A;Albertos, S;Brú, I
用标度技术分析了15个体外生长的细胞系和16种体内发展的肿瘤细胞系的集落的分形性。所有细胞克隆都表现出完全相同的生长动力学--对应于分子束外延(MBE)普适性类别。MBE动力学的特点是：1)线性生长速率；2)细胞增殖受限于集落/肿瘤边缘；3)生长边缘细胞表面扩散。这些特征在被研究的群体中得到了实验验证。这些应该显示MBE动力学与目前建立的肿瘤生长的概念形成强烈对比：这种类型的增殖动力学排除了指数或冈培兹生长的可能性。相反，它遵循了一个明确的线性增长机制。新的细胞运动--肿瘤边界的细胞扩散--的重要性在于，肿瘤的生长必须被认为是肿瘤和宿主之间的空间竞争，而不是为了营养或其他因素。对16种类型的肿瘤提出了强有力的实验证据，其中细胞表面扩散可能是体内负责的主要机制。这些结果解释了大多数集落和肿瘤的临床和生物学特征，提供了新的理论框架，并挑战了一些当前临床策略的智慧。
Scaling techniques were used to analyze the fractal nature of colonies of 15 cell lines growing in vitro as well as of 16 types of tumor developing in vivo. All cell colonies were found to exhibit exactly the same growth dynamics - which correspond to the molecular beam epitaxy (MBE) universality class. MBE dynamics are characterized by 1), a linear growth rate, 2), the constraint of cell proliferation to the colony/tumor border, and 3), surface diffusion of cells at the growing edge. These characteristics were experimentally verified in the studied colonies. That these should show MBE dynamics is in strong contrast with the currently established concept of tumor growth: the kinetics of this type of proliferation rules out exponential or Gompertzian growth. Rather, a clear linear growth regime is followed. The importance of new cell movements - cell diffusion at the tumor border - lies in the fact that tumor growth must be conceived as a competition for space between the tumor and the host, and not for nutrients or other factors. Strong experimental evidence is presented for 16 types of tumor, the growth of which cell surface diffusion may be the main mechanism responsible in vivo. These results explain most of the clinical and biological features of colonies and tumors, offer new theoretical frameworks, and challenge the wisdom of some current clinical strategies.