VND, A GENE REQUIRED FOR EARLY NEUROGENESIS OF DROSOPHILA, ENCODES A HOMEODOMAIN PROTEIN
VND, A GENE REQUIRED FOR EARLY NEUROGENESIS OF DROSOPHILA, ENCODES A HOMEODOMAIN PROTEIN
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DOI：
10.1002/j.1460-2075.1995.tb07355.x
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发表时间：
1995-07-17
期刊：
影响因子：
11.4
通讯作者：
WHITE, K
中科院分区：
文献类型：
--
作者：
JIMENEZ, F;MARTINMORRIS, LE;WHITE, K
果蝇中枢神经系统的发育是由神经细胞（神经祖细胞）从胚胎神经外胚层分离开始的，这一过程至少受到两类基因的指导：无毛鳞片复合物（AS-C）前基因和神经原基因。一段时间以来，人们已经知道AS-C的功能缺失突变会导致神经发育不全，第一个观察到的缺陷是部分神经母细胞分离失败。已知腹侧神经系统缺陷（vnd）位点的功能丧失突变可导致早期神经发生中类似的表型缺陷。最近，vnd基因座被认为与前缘AS-C基因和分裂复合体增强子的神经源性基因的调控有关。在本文中，我们报道了与vnd位点相关的转录物的鉴定，转录物在胚胎发生中的分布与该基因描述的神经系统突变表型相容，并且该蛋白产物是NK-2同源结构域家族的成员。我们在早期果蝇神经发生和与vnd位点相关的已知表型的框架内讨论这些发现。
The development of the central nervous system in Drosophila is initiated by the segregation of neuroblasts, the neural progenitors, from the embryonic neuroectoderm, This process is guided by at least two classes of genes: the achaete-scute complex (AS-C) proneural genes and the neurogenic genes. It has been known for some time that loss-of-function mutations in the AS-C result in neural hypoplasia and the first observed defect is failure of segregation of a fraction of neuroblasts. Loss-of-function mutations at the ventral nervous system defective (vnd) locus are known to lead to similar phenotypic defects in early neurogenesis. More recently, the vnd locus has been implicated in the regulation of the proneural AS-C genes and the neurogenic genes of the Enhancer of spilt complex. In this paper we report the identification of a transcript associated with the vnd locus, the transcript distribution in embryogenesis, which is compatible with the nervous system mutant phenotypes described for this gene, and that the protein product is a member of the NK-2 homeodomain family. We discuss these findings within the framework of early Drosophila neurogenesis and the known phenotypes associated with the vnd locus.