An exploratory study of the effect of regular aquatic exercise on the function of neutrophils from women with fibromyalgia: Role of IL-8 and noradrenaline
An exploratory study of the effect of regular aquatic exercise on the function of neutrophils from women with fibromyalgia: Role of IL-8 and noradrenaline
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DOI：
10.1016/j.bbi.2013.11.009
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发表时间：
2014-07-01
影响因子：
15.1
通讯作者：
Ortega, E.
中科院分区：
文献类型：
--
作者：
Bote, M. E.;Garcia, J. J.;Ortega, E.
纤维肌痛(FM)综合征与全身炎症和应激生物标志物升高以及单核细胞和中性粒细胞介导的固有细胞反应升高有关。运动被认为是治疗FM的一种良好的非药物疗法。我们之前已经发现，定期水上运动可以减少FM患者单核细胞释放炎性细胞因子。然而，它对中性粒细胞功能能力的影响还没有研究。本探索性研究的目的是对10名确诊为FM的女性进行水上运动(8个月，2次/周，60min/次)对中性粒细胞功能(吞噬过程)的影响，以及对IL-8和NA作为潜在炎症和应激介质的影响。经过4个月的锻炼，中性粒细胞功能(趋化、吞噬或杀菌能力)、IL-8和NA均未见明显变化。然而，在运动计划(8个月)结束时，观察到神经-免疫-内分泌适应，表现为中性粒细胞趋化性、IL-8和NA显著下降到低于基础状态的值。在同一时期，在非运动性FM患者组中，这些参数没有明显的季节性变化。在8个月的锻炼计划后，FM患者的IL-8和NA浓度以及中性粒细胞趋化性降低，与同月未锻炼的FM女性对照组相比。这些结果表明，抗炎和抗应激适应可能有助于经常水上运动对FM综合征症状的改善，本研究通过纤维肌痛影响问卷的得分证实了这一点。(C)2013 Elsevier Inc.保留所有权利。
Fibromyalgia (FM) syndrome is associated with elevated systemic inflammatory and stress biomarkers, and an elevated innate cellular response mediated by monocytes and neutrophils. Exercise is accepted as a good non-pharmacological therapy for FM. We have previously found that regular aquatic exercise decreases the release of inflammatory cytokines by monocytes from FM patients. However, its effects on the functional capacity of neutrophils have not been studied. The aim of the present exploratory study was to evaluate, in 10 women diagnosed with FM, the effect of an aquatic exercise program (8 months, 2 sessions/week, 60 min/session) on their neutrophils' function (phagocytic process), and on IL-8 and NA as potential inflammatory and stress mediators, respectively. A control group of 10 inactive FM patients was included in the study.After 4 months of the exercise program, no significant changes were observed in neutrophil function (chemotaxis, phagocytosis, or fungicidal capacity) or in IL-8 and NA. However, at the end of the exercise program (8 months), a neuro-immuno-endocrine adaptation was observed, manifested by a significant decrease to values below those in the basal state in neutrophil chemotaxis, IL-8, and NA. No significant seasonal changes in these parameters were observed during the same period in the group of non-exercised FM patients. After the 8 months of the exercise program, the FM patients had lower concentrations of IL-8 and NA together with reduced chemotaxis of neutrophils compared with the values determined in the same month in the control group of non-exercised FM women.These results suggest that "anti-inflammatory" and "anti-stress" adaptations may be contributing to the symptomatic benefits that have been attributed to regular aquatic exercise in FM syndrome, as was corroborated in the present study by the scores on the Fibromyalgia Impact Questionnaire. (C) 2013 Elsevier Inc. All rights reserved.