Oxytocin plasma concentrations after single intranasal oxytocin administration - A study in healthy men
Oxytocin plasma concentrations after single intranasal oxytocin administration - A study in healthy men
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DOI：
10.1016/j.npep.2012.07.001
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发表时间：
2012-10-01
期刊：
影响因子：
2.9
通讯作者：
Spreckelmeyer, K. N.
中科院分区：
文献类型：
--
作者：
Gossen, A.;Hahn, A.;Spreckelmeyer, K. N.
神经肽催产素已成为研究人类社会认知的一个非常感兴趣的主题。据报道，单次鼻内给予激素具有积极的行为效应，例如在给药后45-80分钟增加信任或促进社会交往。然而，关于催产素鼻喷雾剂在人体中的长期药代动力学仍然知之甚少。这项研究解决了这样一个问题，即鼻喷雾剂给药后催产素血浆水平保持升高多久。另一个目标是检查催产素给药对内源性类固醇激素的影响，因为这种改变可能通过间接的方式调节社会行为。八名健康的白人男子挑战与单鼻内应用26国际单位的催产素。在3.5小时内的5个连续时间点（相对于催产素施用的-5、+30、+90、+150、+210分钟）评估催产素血浆水平以及孕酮、睾酮和雌二醇的类固醇激素水平的变化。结果表明，鼻内给药后30分钟，8名参与者中有7名观察到催产素血浆水平大幅上升。组平均催产素血浆水平已恢复到基线后90分钟给药，虽然在一些人的血浆水平仍然升高相对于采样后150分钟。类固醇激素分析产生了轻微的增强内源性睾酮水平后210分钟催产素给药。我们的数据证实了以前的发现，即催产素作为鼻喷雾剂进入血液循环，在有限的时间内提高催产素血浆水平。我们的研究结果表明，这个时间窗在个体之间是不同的，但是，对于所使用的剂量，它不会超过给药后150分钟。这些数据进一步提供了初步证据，表明鼻内催产素对健康男性的睾酮具有增强作用。(c)2012爱思唯尔有限公司保留所有权利。
The neuropeptide oxytocin has become a subject of great interest in studies investigating human social cognition. Single intranasal administration of the hormone has been reported to have positive behavioral effects, such as increasing trust or facilitating social approach, 45-80 min after administration. However, little is still known about the long-term pharmacokinetics of oxytocin nasal spray application in humans. This study addressed the question how long oxytocin plasma levels remain elevated following nasal spray administration. Another goal was to examine the influence of oxytocin administration on endogenous steroid hormones since such alterations might modulate social behavior via an indirect way. Eight healthy Caucasian men were challenged with a single intranasal application of 26 international units of oxytocin. Changes in oxytocin blood plasma levels, as well as steroid hormone levels of progesterone, testosterone and estradiol were assessed at 5 consecutive time points over a period of 3.5 h (-5, +30, +90, +150, +210 min relative to oxytocin administration). Results gave evidence for a substantial rise of oxytocin plasma levels 30 min after intranasal administration, observed in 7 of 8 participants. Group mean oxytocin plasma level was found to have returned to baseline already 90 min post administration, though in some individuals the plasma levels was still elevated relative to sampling at post 150 min. Steroid hormone analyses yielded a slight augmentation of endogenous testosterone levels 210 min after oxytocin administration. Our data confirms previous findings that oxytocin administered as a nasal spray enters the blood circulation, elevating oxytocin plasma levels for a limited time. Our findings suggest that this time window differs between individuals, but that, for the used dose, it does not extend beyond 150 min post administration. The data further provides preliminary evidence that intranasal oxytocin has an enhancing effect on testosterone in healthy men. (c) 2012 Elsevier Ltd. All rights reserved.