Repeated core temperature elevation induces conduit artery adaptation in humans
Repeated core temperature elevation induces conduit artery adaptation in humans
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DOI：
10.1007/s00421-013-2817-2
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发表时间：
2014-04-01
影响因子：
3
通讯作者：
Green, Daniel J.
中科院分区：
文献类型：
--
作者：
Carter, Howard H.;Spence, Angela L.;Green, Daniel J.
剪切应力是人类血管适应的已知刺激。然而，它是不知道是否体温调节反射增加血流和剪切可以诱导导管arteryadaptation.10名健康的年轻志愿者，因此，进行了8周的3 ×每周发作的30分钟下肢加热（40摄氏度），在此期间，上身不直接加热。在每次腿部加热过程中，在一侧前臂上放置一个充气袖带并充气以限制反射介导的血流反应。每次腿部加热都显著增加了无袖带手臂的肱动脉剪切率（96 +/- A 97 vs 401 +/- A 96 l/s，P < 0.01），而套囊组无明显变化（83 +/- A 69 vs 131 +/- A 76 l/s，P = 0.67）。从第0周（5.2 +/-A1.9%）到第4周（7.7 +/-A2.6%，P < 0.05），重复间歇性暴露于腿部加热增强了无袖带手臂的肱动脉内皮功能（通过血流介导的扩张测量），然后在第8周恢复到基线水平。没有适应是显而易见的，在袖口arm.We得出结论，重复增加核心温度，通过下肢加热诱导，导致上肢管道动脉血管适应这是依赖于增加剪切应力。据我们所知，这是第一个研究，以建立一个有益的全身影响的体温调节反射对管道动脉功能在人类。
Shear stress is a known stimulus to vascular adaptation in humans. However, it is not known whether thermoregulatory reflex increases in blood flow and shear can induce conduit artery adaptation.Ten healthy young volunteers therefore underwent 8 weeks of 3 x weekly bouts of 30 min lower limb heating (40 A degrees C) during which the upper body was not directly heated. Throughout each leg heating session, a pneumatic cuff was placed on one forearm and inflated to unilaterally restrict reflex-mediated blood flow responses.Each bout of leg heating significantly increased brachial artery shear rate in the uncuffed arm (96 +/- A 97 vs 401 +/- A 96 l/s, P < 0.01), whereas no change was apparent in the cuffed arm (83 +/- A 69 vs 131 +/- A 76 l/s, P = 0.67). Repeated episodic exposure to leg heating enhanced brachial artery endothelial function (measured by flow-mediated dilation) in the uncuffed arm from week 0 (5.2 +/- A 1.9 %) to week 4 (7.7 +/- A 2.6 %, P < 0.05), before returning to baseline levels by week 8. No adaptation was evident in the cuffed arm.We conclude that repeated increases in core temperature, induced via lower limb heating, resulted in upper limb conduit artery vascular adaptation which was dependent upon increases in shear stress. To our knowledge this is the first study to establish a beneficial systemic impact of thermoregulatory reflexes on conduit artery function in humans.