The dorsal premotor cortex orchestrates concurrent speech and fingertapping movements
The dorsal premotor cortex orchestrates concurrent speech and fingertapping movements
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DOI：
10.1111/j.1460-9568.2009.06729.x
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发表时间：
2009-05-01
影响因子：
3.4
通讯作者：
Sparing, Roland
中科院分区：
文献类型：
--
作者：
Meister, Ingo G.;Buelte, Dorothee;Sparing, Roland
人类的言语和手的使用都涉及高度专业化的复杂运动模式。尽管之前的研究详细描述了介导语音和手指运动的皮层运动系统，但迄今为止提供并发语音和手部运动协调的网络尚不清楚。本研究利用功能磁共振成像（fMRI），研究了专门用于语音或手指敲击的差异皮层网络，以及介导这些涉及不同效应器的复杂运动模式整合的区域。连接对比揭示了在唯一的手指敲击和唯一的重复发音或大声朗读期间激活的区域显示了腹侧和背侧运动皮层边界的对侧区域。相比之下，分析显示，与单手运动或重复发音或大声朗读相比，两个效应器同时运动的功能磁共振成像激活水平更高的区域显示出明显的运动前激活，这些区域位于言语和指压任务激活区域的背侧和尾侧。这些结果表明前运动皮层 (PMC) 有助于同时言语与手部动作的协调。该整合运动区域与显示语音和手指敲击重叠激活的区域不同。因此，这些涉及不同效应器的复杂运动模式的并发执行，除了体位运动皮层激活之外，还需要由不同的 PMC 区域进行协调。
Human speech and hand use both involve highly specialized complex movement patterns. Whereas previous studies in detail characterized the cortical motor systems mediating speech and finger movements, the network that provides coordination of concurrent speech and hand movements so far is unknown. Using functional magnetic resonance imaging (fMRI), the present study investigated differential cortical networks devoted to speech or fingertapping, and regions mediating integration of these complex movement patterns involving different effectors. The conjunction contrasts revealing regions activated both during sole fingertapping and sole repetitive articulation or reading aloud showed contralateral regions at the border of ventral and dorsal motor cortex. In contrast, the analyses revealing regions showing a higher level of fMRI activation for concurrent movements of both effectors compared with sole hand movements or repetitive articulation or reading aloud showed distinct premotor activations, which were situated dorsal and caudal to the areas activated across speech and fingertapping tasks. These results indicate that the premotor cortex (PMC) subserves coordination of concurrent speech with hand movements. This integrative motor region is not identical with the area that shows overlapping activations for speech and fingertapping. Thus, concurrent performance of these complex movement patterns involving different effectors requires, in addition to somatotopic motor cortex activation, orchestration subserved by a distinct PMC area.