Clinical isolates of Staphylococcus aureus with ribosomal mutations conferring resistance to macrolides
Clinical isolates of Staphylococcus aureus with ribosomal mutations conferring resistance to macrolides
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DOI：
10.1128/aac.46.9.3054-3056.2002
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发表时间：
2002-09-01
影响因子：
4.9
通讯作者：
Leclercq, R
中科院分区：
文献类型：
--
作者：
Prunier, AL;Malbruny, B;Leclercq, R
从囊性纤维化患者阿奇霉素治疗后分离的6株金黄色葡萄球菌对阿奇霉素和红霉素交叉耐药。这些分离株均不含rr 1或msr（A）基因，但它们都在rr 1基因内携带A2058 G/U或A2059 G突变，大部分rRNA拷贝携带该突变。一个菌株在编码L22核糖体蛋白的rpIV基因中显示出另外的突变。
Six strains of Staphylococcus aureus isolated from cystic fibrosis patients after treatment with azithromycin were cross-resistant to azithromycin and erythromycin. None of the isolates contained erm or msr(A) genes, but they all carried either A2058G/U or A2059G mutations within the rrl genes, with a majority of the rRNA copies bearing the mutation. One strain displayed an additional mutation in the rplV gene, encoding the L22 ribosomal protein.