Lung defences: an overview
Lung defences: an overview
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DOI：
10.1183/09059180.05.00009501
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发表时间：
2005-12-01
影响因子：
7.5
通讯作者：
Nicod, L. P.
中科院分区：
文献类型：
--
作者：
Nicod, L. P.
肺防御依赖于上呼吸道的一系列复杂机制，必须将其与远端呼吸道的机制区分开来。然而，近端和远端气道中的第一道防线主要基于机械屏障和与先天免疫相关的几种机制。如果病原体或抗原到达肺，树突状细胞将吸收这些入侵者，将抗原信息报告给肺淋巴结，在那里产生适应性免疫。树突状细胞，通过这样做，桥梁先天免疫与适应性免疫。了解这些机制是调节免疫力以增加防御机制或减少过敏现象的关键。
Lung defences are dependant on a complex array of mechanisms in the upper airways, which must to be differentiated from those of the distal airways. However, the first lines of defence in the proximal and distal airways are predominantly based on mechanical barriers and several mechanisms related to innate immunity. If pathogens or antigens reach the interstitium, dendritic cells will take up these intruders, reporting antigenic information to the pulmonary lymph nodes, where an adaptive immunity will be generated. Dendritic cells, by doing so, bridge innate immunity with adaptive immunity. Knowledge of these mechanisms is key when modulating immunity to increase defence mechanisms or decrease allergic phenomena.