Association between deficiency of mannose-binding lectin and severe infections after chemotherapy
Association between deficiency of mannose-binding lectin and severe infections after chemotherapy
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DOI：
10.1016/s0140-6736(01)05785-3
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发表时间：
2001-08-25
期刊：
影响因子：
168.9
通讯作者：
Thiel, S
中科院分区：
文献类型：
--
作者：
Peterslund, NA;Koch, C;Thiel, S
The plasma protein mannose-binding lectin (MBL) activates the complement system by binding to carbohydrate structures presented by microorganisms and thus could be an important component of the innate immune defence system. We measured MBL in patients with leukaemia who were scheduled to undergo chemotherapy (ie, a population especially susceptible to infection) and related the results to severity of infection after chemotherapy. We showed a significant association between low concentrations of MBL and serious infections related to chemotherapy (p
