The comparative histology of porcine and guinea pig skin with respect to iontophoretic drug delivery.
The comparative histology of porcine and guinea pig skin with respect to iontophoretic drug delivery.
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DOI：
10.1016/0031-6865(94)00050-6
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发表时间：
1995-04-01
期刊：
影响因子：
--
通讯作者：
Lochner, D H
中科院分区：
文献类型：
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作者：
Ferry, L L;Argentieri, G;Lochner, D H
研究了猪皮肤、新生猪皮肤和无毛豚鼠皮肤的离子电渗药物转运解剖学。用苏木精和伊红对皮肤的固定切片进行染色，并检查皮肤附件的形态。定量测量毛囊密度、直径和管腔面积，并计算可用于低电阻离子电渗运输的有效表面积。新生猪皮肤和无毛豚鼠皮肤毛囊的聚集和密度表明，线性质量传输可能占主导地位的离子导入通量。相比之下，猪皮肤毛囊的形态和密度表明，径向质量传输机制可能占主导地位的离子电渗经皮给药。
The anatomy of pig skin, neonatal pig skin, and hairless guinea pig skin was investigated with respect to iontophoretic drug transport. Fixed sections of skin were stained with hematoxylin and eosin, and the morphology of the skin appendages was examined. Quantitative measurements of the hair follicle density, diameter and lumen area were obtained, and the effective surface areas available for low resistance iontophoretic transport were calculated. The clustering and density of the follicles of neonatal porcine skin and hairless guinea pig skin suggest that linear mass transport may dominate iontophoretic flux. In contrast, the morphology and density of the hair follicles of porcine skin suggests that a radial mass transport mechanism may dominate iontophoretic transdermal drug delivery.