DEHYDROEPIANDROSTERONE REDUCES SERUM LOW-DENSITY LIPOPROTEIN LEVELS AND BODY-FAT BUT DOES NOT ALTER INSULIN SENSITIVITY IN NORMAL MEN
DEHYDROEPIANDROSTERONE REDUCES SERUM LOW-DENSITY LIPOPROTEIN LEVELS AND BODY-FAT BUT DOES NOT ALTER INSULIN SENSITIVITY IN NORMAL MEN
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DOI：
10.1210/jcem-66-1-57
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发表时间：
1988-01-01
影响因子：
5.8
通讯作者：
BLACKARD, WG
中科院分区：
文献类型：
--
作者：
NESTLER, JE;BARLASCINI, CO;BLACKARD, WG
为了评估脱氢表雄酮（DHEA）对体脂量、血脂水平和组织对胰岛素敏感性的影响，在一项随机、双盲研究中，5名正常男性接受安慰剂，5名正常男性接受口服DHEA [1600 mg/天（554.7 mmol/天）]，持续28天。在DHEA组中，血清DHEA-S水平升高2.5- 3.5倍，平均（±）. SEM）血清雄烯二酮从4.3 . ±. 0.6至8.6 .+-。1.2 nmol/L（P < 0.004，配对t检验），但血清总睾酮、游离睾酮、性激素结合球蛋白、雌二醇和雌酮水平无变化。在DHEA组中，平均体脂百分比下降了31%，体重没有变化。这表明脂肪量的减少与肌肉量的增加相结合。DHEA给药也导致平均血清总胆固醇浓度下降（4.82 ± 0.001）。0.21与4.48 .+-. 0.29 nmol/L; P < 0.05），这几乎完全是由于平均血清低密度脂蛋白胆固醇下降7.5%（3.21 ± 0.05）。0.11与2.97 . ±. 0.14 nmol/L; P < 0.01）。安慰剂组的人体测量参数或血脂水平无变化。组织对胰岛素的敏感性，通过高胰岛素-正葡萄糖钳夹技术评估，在安慰剂组或DHEA组中没有改变。这些结果表明，在正常男性DHEA管理减少体脂肪，增加肌肉质量，并降低血清低密度脂蛋白胆固醇水平。组织对胰岛素的敏感性不受短期DHEA管理。
To assess the effects of dehydroepiandrosterone (DHEA) on body fat mass, serum lipid levels, and tissue sensitivity to insulin, five normal men were given placebo and five normal men were given oral DHEA [1600 mg/day (554.7 mmol/day)] for 28 days in a randomized, double blind study. In the DHEA group serum DHEA-S levels rose 2.5- to 3.5-fold, and mean (.+-. SEM) serum androstenedione rose from 4.3 .+-. 0.6 to 8.6 .+-. 1.2 nmol/L (P < 0.004, by paired t test), but serum total testosterone, free testosterone, sex hormone-binding globulin, estradiol, and estrone levels did not change. In the DHEA group the mean percent body fat decreased by 31%, with no change in weight. This suggests that the reduction in fat mass was coupled with an increase in muscle mass. DHEA administration also resulted in a fall in mean serum total cholesterol concentration (4.82 .+-. 0.21 vs. 4.48 .+-. 0.29 nmol/L; P < 0.05), which was due almost entirely to a fall of 7.5% in mean serum low density lipoprotein cholesterol (3.21 .+-. 0.11 vs. 2.97 .+-. 0.14 nmol/L; P < 0.01). No changes in anthropometric parameters or serum lipid levels occurred in the placebo group. Tissue sensitivity to insulin, assessed by the hyperinsulinemic-euglycemic clamp technique, did not change in either the placebo or DHEA groups. These results suggest that in normal men DHEA administration reduces body fat, increases muscle mass, and reduces serum low density lipoprotein cholesterol levels. Tissue sensitivity to insulin was unaffected by short term DHEA administration.