Biochemical insights into the role of matrix metalloproteinases in regeneration: challenges and recent developments.
Biochemical insights into the role of matrix metalloproteinases in regeneration: challenges and recent developments.
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DOI：
10.4155/fmc.09.83
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发表时间：
2009-09
影响因子：
4.2
通讯作者：
Li Y
中科院分区：
文献类型：
--
作者：
Bellayr IH;Mu X;Li Y
基质金属蛋白酶（MMP）是一组属于metazincin家族的蛋白酶。这些蛋白质由类似的结构组成，其特征在于信号肽、前肽结构域、催化结构域（其中发现显著的锌离子结合位点）和结合至C末端血丛蛋白结构域的铰链区。MMPs可由多种细胞类型通过分泌或定位于细胞膜而产生。虽然已知某些化合物通常抑制MMP，但称为金属蛋白酶组织抑制剂（TIMP）的天然存在的蛋白质有效地与MMP相互作用以改变其生物学作用。基质金属蛋白酶是一种非常重要的酶，它通过降解某些成分积极参与细胞外基质的重塑，沿着促进细胞增殖、迁移、分化、凋亡和血管生成。在正常成人组织中，它们几乎检测不到;然而，当受到损伤、疾病或妊娠的干扰时，它们的表达会升高。本综述的目的是确定新的实验结果，提供了进一步了解基质金属蛋白酶在骨骼肌，神经和皮肤组织，以及在肝脏，心脏和肾脏的作用。MMP的表达增加可以改善伤口的再生潜力;然而，MMP和TIMP表达之间的不平衡可以证明对受影响的组织是破坏性的。
Matrix metalloproteinases (MMPs) are a group of proteases that belong to the metazincin family. These proteins consist of similar structures featuring a signaling peptide, a propeptide domain, a catalytic domain where the notable zinc ion binding site is found and a hinge region that binds to the C-terminal hemoplexin domain. MMPs can be produced by numerous cell types through secretion or localization to the cell membrane. While certain chemical compounds have been known to generally inhibit MMPs, naturally occurring proteins known as tissue inhibitors of metalloproteinases (TIMPs) effectively interact with MMPs to modify their biological roles. MMPs are very important enzymes that actively participate in remodeling the extracellular matrix by degrading certain constituents, along with promoting cell proliferation, migration, differentiation, apoptosis and angiogenesis. In normal adult tissue, they are almost undetectable; however, when perturbed through injury, disease or pregnancy, they have elevated expression. The goal of this review is to identify new experimental findings that have provided further insight into the role of MMPs in skeletal muscle, nerve and dermal tissue, as well as in the liver, heart and kidneys. Increased expression of MMPs can improve the regeneration potential of wounds; however, an imbalance between MMP and TIMP expression can prove to be destructive for afflicted tissues.
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影响因子：
4.9
作者：
Akhavani MA;Madden L;Buysschaert I;Sivakumar B;Kang N;Paleolog EM
通讯作者：
Paleolog EM
影响因子：
1.5
作者：
Alagoz, MS;Uysal, CA;Sensoz, O
通讯作者：
Sensoz, O
DOI：
10.1152/ajpheart.00511.2002
发表时间：
2003-01-01
影响因子：
4.8
作者：
Creemers, EEJM;Davis, JN;Spinale, FG
通讯作者：
Spinale, FG
影响因子：
3.3
作者：
Caron, NJ;Asselin, I;Tremblay, JP
通讯作者：
Tremblay, JP
影响因子：
7.4
作者：
Castro, Michele M.;Rizzi, Elen;Tanus-Santos, Jose E.
通讯作者：
Tanus-Santos, Jose E.