Effect of Iron Therapy on Platelet Counts in Patients with Inflammatory Bowel Disease-Associated Anemia
Effect of Iron Therapy on Platelet Counts in Patients with Inflammatory Bowel Disease-Associated Anemia
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DOI：
10.1371/journal.pone.0034520
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发表时间：
2012-04-10
期刊：
影响因子：
3.7
通讯作者：
Gasche, Christoph
中科院分区：
文献类型：
--
作者：
Kulnigg-Dabsch, Stefanie;Evstatiev, Rayko;Gasche, Christoph
背景和目的：继发性血小板增多症是一种临床特征，临床意义不明。在炎症性肠病(IBD)中，血小板增多被认为是活动性疾病的标志；然而，缺铁本身可能会引发血小板生成。在这项研究中，我们测试了铁治疗对IBD相关性贫血患者血小板计数的影响。方法：从四个前瞻性临床试验中分析铁治疗前后的血小板计数。此外，还比较了铁治疗前后血红蛋白、转铁蛋白饱和度、铁蛋白、C反应蛋白和白细胞计数的变化。在一个亚组中，测试了促红细胞生成素治疗的效果。结果：共有308例患者病历可用于初步分析。血小板计数呈剂量依赖性下降(平均425G/L至320G/L；p
Background and Aims: Secondary thrombocytosis is a clinical feature of unknown significance. In inflammatory bowel disease (IBD), thrombocytosis is considered a marker of active disease; however, iron deficiency itself may trigger platelet generation. In this study we tested the effect of iron therapy on platelet counts in patients with IBD-associated anemia.Methods: Platelet counts were analyzed before and after iron therapy from four prospective clinical trials. Further, changes in hemoglobin, transferrin saturation, ferritin, C-reactive protein, and leukocyte counts, before and after iron therapy were compared. In a subgroup the effect of erythropoietin treatment was tested. The results were confirmed in a large independent cohort (FERGIcor).Results: A total of 308 patient records were available for the initial analysis. A dose-depended drop in platelet counts (mean 425 G/L to 320 G/L; p