Early In Vivo Evaluation of Ventricular Assistance With a Miniature Centrifugal Blood Pump (TinyPump) in Rabbits
Early In Vivo Evaluation of Ventricular Assistance With a Miniature Centrifugal Blood Pump (TinyPump) in Rabbits
复制标题
家兔微型离心血泵 (TinyPump) 心室辅助的早期体内评估
DOI：
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发表时间：
2010
期刊：
影响因子：
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通讯作者：
R. Tominaga
中科院分区：
文献类型：
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作者：
Taketoshi Maeda;Y. Tanoue;Mariko Kobayashi;H. Baba;Y. Shiokawa;S. Takatani;R. Tominaga
We have developed an ultraminiature centrifugal pump, TinyPump, with a priming volume of 5 ml. The in vivo performance of TinyPump was compared with that of HPM-05 for left ventricular support. Each pump group included seven rabbits weighing 3.4–3.8 kg. One rabbit in the TinyPump group and two rabbits in the HPM-05 group died of unsuccessful cannulation. The remaining rabbits (six in the TinyPump group and five in the HPM-05 group) were instrumented and observed for 240 minutes. The pump flow was maintained at around 200 ml/min. The priming volumes of the entire circuits were 25 and 45 ml for TinyPump and HPM-05, respectively. TinyPump required a higher rotation speed (2214 ± 47 vs. 1261 ± 87 rpm, p < 0.05) because of its small priming volume but showed a similar plasma free hemoglobin level to HPM-05. The hematocrit values were kept higher in the TinyPump group during ventricular support (24.3 ± 1.4% vs. 20.1 ± 1.4% at 240 minutes, p < 0.05). The mean arterial pressure did not differ between the two groups. The biochemical parameters were also equivalent in the two groups. Overall, TinyPump exhibited a feasible in vivo performance. This ultraminiature device would offer promising outcomes for neonates and infants with intractable heart failure.
影响因子：
158.5
作者：
Rose, EA;Gelijns, AC;Meier, P
通讯作者：
Meier, P