Cutaneous melanomas associated with nevi
Cutaneous melanomas associated with nevi
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DOI：
10.1001/archderm.139.12.1620
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发表时间：
2003-12-01
影响因子：
--
通讯作者：
Tsao, H
中科院分区：
文献类型：
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作者：
Bevona, C;Goggins, W;Tsao, H
目的：为了确定黑色素瘤的发生率以及与黑色素瘤组织学邻近痣相关的组织学和临床因素，设计：回顾性分析了从1993年1月1日至1997年12月31日收集的黑色素瘤的病理报告。无。主要结果测量：黑色素瘤之间的组织学（亚型，Breslow厚度和Clark水平）和临床（年龄，性别和解剖位置）特征的差异，相关和不相关的nevus.Results：26%的黑色素瘤审查组织学相关痣（发育不良痣，43.0%;和其他痣，57.0%）。与黑色素瘤组织学上与痣相邻的可能性增加显著相关的因素包括年龄较小，浅表扩散亚型，躯干位置，Breslow厚度和Clark水平。然而，经过多变量分析，只有年轻的年龄，（比值比，1.27; 95%置信区间，1.19-1.37），浅表播散亚型（比值比，2.96; 95%置信区间，2.17-4.02），和躯干位置（优势比，3.26; 95%置信区间，2.55-4.19）仍然显着。结论：大多数黑色素瘤是不连续的痣组织学。年轻、浅表扩散亚型和躯干部位是黑色素瘤与痣组织学相关的独立重要预测因素。
Objective: To determine the frequency of and the histologic and clinical factors associated with melanoma existing in histologic contiguity with a nevus.Design: Pathology reports from melanomas collected from January 1, 1993, to December 31, 1997, were retrospectively reviewed.Setting: Independent, community-based dermatopathology laboratory.Patients: A total of 1606 patients with a histologic diagnosis of melanoma.Intervention: None.Main Outcome Measures: Differences in histologic (subtype, Breslow thickness, and Clark level) and clinical (age, sex, and anatomic location) features between melanomas that are associated and unassociated with a nevus.Results: Twenty-six percent of the melanomas reviewed were histologically associated with nevi (dysplastic nevi, 43.0%; and other nevi, 57.0%). Factors that were significantly associated with an increased likelihood of a melanoma being histologically contiguous with a nevus included younger age, superficial spreading subtype, truncal location, Breslow thickness, and Clark level. However, after multivariate analysis, only younger age (odds ratio, 1.27; 95% confidence interval, 1.19-1.37), superficial spreading subtype (odds ratio, 2.96; 95% confidence interval, 2.17-4.02), and truncal location (odds ratio, 3.26; 95% confidence interval, 2.55-4.19) remained significant.Conclusions: Most melanomas were not histologically contiguous with a nevus. Younger age, superficial spreading subtype, and truncal location are independent significant predicators of a melanoma being histologically associated with a nevus.