Urinary Biomarkers for Secondhand Smoke
Urinary Biomarkers for Secondhand Smoke
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DOI：
10.1002/jcla.20485
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发表时间：
2011-01-01
影响因子：
2.7
通讯作者：
Yoshimi, Itsuro
中科院分区：
文献类型：
--
作者：
Ino, Toshihiro;Ohtani, Tetsuya;Yoshimi, Itsuro
使用生物标志物是强制性的定量分析暴露于二手烟（SHS）。本文总结了现在可以量化的烟雾暴露的尿生物标志物。评估暴露于SHS的最可靠的尿液生物标志物是NNAL 4-（甲基亚硝胺）-1-（3-吡啶基）-1-丁醇和NNAL-葡萄糖醛酸苷，这是烟草特异性亚硝胺的代谢产物。这些物质甚至在50%的可替宁水平检测不到的儿童中也被检测到（
The use of a biomarker is mandatory for quantitative analysis of exposure to secondhand smoke (SHS). This article summarizes urinary biomarkers of smoke exposure which can be now quantified. The most reliable urinary biomarkers to assess the exposure to SHS are NNAL 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol and NNAL-Glucuronides, which is metabolites of tobacco-specific nitrosamine. These substances were detected even in 50% of children who had undetectable level of cotinine (