Optimization of tramadol-PVC membrane electrodes using miscellaneous plasticizers and ion-pair complexes
Optimization of tramadol-PVC membrane electrodes using miscellaneous plasticizers and ion-pair complexes
复制标题
DOI：
10.1016/j.msec.2010.09.014
复制
发表时间：
2011-03-12
影响因子：
7.9
通讯作者：
Abou Assi, Anwar A.
中科院分区：
文献类型：
--
作者：
Abu Shawish, Hazem M.;Saadeh, Salman M.;Abou Assi, Anwar A.
研究了 ISE 膜成分对曲马多-PVC 电极特性的影响。研究的参数包括增塑剂的影响和离子对络合物的影响。所用增塑剂为2-硝基苯基辛基醚（2-NPOE）、邻苯二甲酸二辛酯（DOP）、邻苯二甲酸二丁酯（DBP）、磷酸三（2-乙基己基）酯（TEPh）、癸二酸二辛酯（DOS）、磷酸三丁酯（TBPh）和丁基膦酸二丁酯（DBBPh），离子对配合物为硅钨酸曲马多(TD-ST)、硅钼酸盐(TD-SM)。这些电极在成分、寿命、可用 pH 范围和工作浓度范围方面进行了全面表征。结果表明，最佳组合是TD-ST作为离子对配合物和DBP作为增塑剂，生产出具有良好特性的电极。使用 TD-SM 的另一个电极经过测试并产生了接近的结果。本电极显示出盐酸曲马多与几种无机、有机离子、糖和一些常见药物赋形剂的明显区别。该传感器适用于采用电位测定法、标准添加法和校准曲线法测定尿液、牛奶和药物制剂中的盐酸曲马多。所获得的结果令人满意，具有出色的回收率，与其他常规测定方法获得的结果相当，有时甚至更好。 (C) 2010 Elsevier B.V. 保留所有权利。
Effect of the ISE membrane composition on the characteristics of the tramadol-PVC-electrodes has been investigated. The parameters studied include the effect of the plasticizer and the effect of the ion-pair complex. The plasticizers used were 2-nitrophenyl octyl ether (2-NPOE), dioctyl phthalate (DOP), dibutyl phthalate (DBP), tris(2-ethylhexyl) phosphate (TEPh), dioctyl sebacate (DOS), tributyl phosphate (TBPh) and dibutyl butyl phosphonate (DBBPh) and the ion-pair complexes were tramadolium-silicotungstate (TD-ST), silicomolybdate (TD-SM). These electrodes were fully characterized in terms of composition, life span, usable pH range and working concentration range. The results showed that the best combination was TD-ST as the ion-pair complex and DBP as the plasticizer that produced the electrode with favorable characteristics. Another electrode using TD-SM was tested and produced close results. The present electrodes show clear discrimination of tramadol hydrochloride from several inorganic, organic ions, sugars and some common drug excipients. The sensors were applied for determination of tramadol hydrochloride in urine, milk and pharmaceutical preparations using potentiometric determination, standard addition and the calibration curve methods. The results obtained were satisfactory with excellent percentage recovery comparable and sometimes better than those obtained by other routine methods for the assay. (C) 2010 Elsevier B.V. All rights reserved.