HIV Status, Burden of Comorbid Disease, and Biomarkers of Inflammation, Altered Coagulation, and Monocyte Activation
HIV Status, Burden of Comorbid Disease, and Biomarkers of Inflammation, Altered Coagulation, and Monocyte Activation
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DOI：
10.1093/cid/cis406
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发表时间：
2012-07-01
影响因子：
11.8
通讯作者：
Freiberg, Matthew
中科院分区：
文献类型：
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作者：
Armah, Kaku A.;McGinnis, Kathleen;Freiberg, Matthew
背景资料。在普通人群和人类免疫缺陷病毒(HIV)感染者中，炎症、凝血改变和单核细胞激活的生物标志物与死亡率和心血管疾病(CVD)相关。在退伍军人老龄化队列研究中，我们比较了HIV感染者和未感染者之间炎症、凝血改变和单核细胞激活的生物标志物。对1525例HIV感染者和843例非感染者的血液标本进行了炎症(IL-6)、凝血改变(D-二聚体)和单核细胞活化(可溶性CD14[sCD14])生物标志物的检测。使用Logistic回归分析来确定HIV感染与生物标志物升高(>；75%)患病率之间的关系，并对混杂合并症进行了调整。与未感染的退伍军人相比，感染艾滋病毒的退伍军人心血管疾病、高血压、糖尿病、肥胖、危险饮酒和肾脏疾病的患病率较低，但血脂异常、丙型肝炎和目前吸烟的比例较高。与未感染的退伍军人相比，HIV感染的退伍军人HIV-1RNA=500拷贝/毫升或CD4计数
Background. Biomarkers of inflammation, altered coagulation, and monocyte activation are associated with mortality and cardiovascular disease (CVD) in the general population and among human immunodeficiency virus (HIV)-infected people. We compared biomarkers for inflammation, altered coagulation, and monocyte activation between HIV-infected and uninfected people in the Veterans Aging Cohort Study (VACS).Methods. Biomarkers of inflammation (interleukin-6 [IL-6]), altered coagulation (D-dimer), and monocyte activation (soluble CD14 [sCD14]) were measured in blood samples from 1525 HIV-infected and 843 uninfected VACS participants. Logistic regression was used to determine the association between HIV infection and prevalence of elevated (>75th percentile) biomarkers, adjusting for confounding comorbidities.Results. HIV-infected veterans had less prevalent CVD, hypertension, diabetes, obesity, hazardous drinking, and renal disease, but more dyslipidemia, hepatitis C, and current smoking than uninfected veterans. Compared to uninfected veterans, HIV-infected veterans with HIV-1 RNA >= 500 copies/mL or CD4 count