Association of Kidney Function With Coronary Atherosclerosis and Calcification in Autopsy Samples From Japanese Elders: The Hisayama Study
Association of Kidney Function With Coronary Atherosclerosis and Calcification in Autopsy Samples From Japanese Elders: The Hisayama Study
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DOI：
10.1053/j.ajkd.2009.06.034
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发表时间：
2010-01-01
影响因子：
13.2
通讯作者：
Sueishi, Katsuo
中科院分区：
文献类型：
--
作者：
Nakano, Toshiaki;Ninomiya, Toshiharu;Sueishi, Katsuo
背景：慢性肾脏病（CKD）与冠心病风险增加相关。然而，关于CKD患者冠状动脉粥样硬化的组织病理学特征的信息很少。本研究调查了CKD和基于人群的尸检样本中冠状动脉粥样硬化严重程度之间的关系。研究设计：横断面研究。设置和参与者：从844个连续基于人群的尸检样本中随机选择126个个体。预测因素：使用6变量肾脏疾病饮食改良（MDRD）研究方程计算的估计肾小球滤过率（eGFR）。结果：3支主要冠状动脉粥样硬化的严重程度，包括使用美国心脏协会分类定义的动脉粥样硬化病变类型;狭窄率;和冠状动脉钙化病变。测量：CKD和冠状动脉粥样硬化严重程度之间的关系使用广义估计方程方法进行评估。随着eGFR降低，晚期动脉粥样硬化病变的发生率逐渐增加（对于eGFR>= 60、45-59、30-44和45-59，分别为33.6%、41.7%、52.3%和52.8%）。
Background: Chronic kidney disease (CKD) is associated with increased risk of coronary heart disease. However, information regarding the histopathologic characteristics of coronary atherosclerosis in individuals with CKD is scarce. This study investigated the relationship between CKD and severity of coronary atherosclerosis in population-based autopsy samples.Study Design: Cross-sectional study.Setting & Participants: 126 individuals randomly selected from 844 consecutive population-based autopsy samples.Predictor: Estimated glomerular filtration rate (eGFR) calculated using the 6-variable Modification of Diet in Renal Disease (MDRD) Study equation.Outcomes: Severity of atherosclerosis in 3 main coronary arteries, including atherosclerotic lesion types defined using the American Heart Association classification; stenosis rates; and coronary calcified lesions.Measurements: The relationship between CKD and severity of coronary atherosclerosis was evaluated using generalized estimating equation methods.Results: Frequencies of advanced atherosclerotic lesions increased gradually as eGFR decreased (33.6%, 41.7%, 52.3%, and 52.8% for eGFRs >= 60, 45-59, 30-44, and