Innate Immune Recognition in Infectious and Noninfectious Diseases of the Lung
Innate Immune Recognition in Infectious and Noninfectious Diseases of the Lung
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DOI：
10.1164/rccm.200909-1427so
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发表时间：
2010-06-15
影响因子：
24.7
通讯作者：
Suttorp, Norbert
中科院分区：
文献类型：
--
作者：
Opitz, Bastian;van Laak, Vincent;Suttorp, Norbert
呼吸道疾病是世界人口死亡的主要原因之一。越来越多的证据表明，先天免疫系统及其模式识别受体(PRRs)在感染性和非感染性肺部疾病中都发挥着关键作用，这些疾病包括肺炎、慢性阻塞性肺疾病、急性肺损伤、尘肺和哮喘。PRRs能够感知不同的微生物以及细胞损伤后释放的内源分子。这种PRR参与是启动对感染和组织损伤的免疫反应的先决条件，感染和组织损伤对宿主可能是有利的，也可能是有害的。PRRs包括Toll样受体、NOD样受体、RIG-I样受体和胞浆DNA感受器。PRRs及其信号通路是各种肺部疾病预防和治疗干预的良好靶点。
Diseases of the respiratory tract are among the leading causes of death in the world population. Increasing evidence points to a key role of the innate immune system with its pattern recognition receptors (PRRs) in both infectious and noninfectious lung diseases, which include pneumonia, chronic obstructive pulmonary disease, acute lung injury, pneumoconioses, and asthma. PRRs are capable of sensing different microbes as well as endogenous molecules that are released after cell damage. This PRR engagement is the prerequisite for the initiation of immune responses to infections and tissue injuries which can be beneficial or detrimental to the host. PRRs include the Toll-like receptors, NOD-like receptors, RIG-I like receptors, and cytosolic DNA sensors. The PRRs and their signaling pathways represent promising targets for prophylactic and therapeutic interventions in various lung diseases.