Effectiveness of Hyperthermia on Cancer Stem Cells
Effectiveness of Hyperthermia on Cancer Stem Cells
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DOI：
10.3191/thermalmed.33.29
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发表时间：
2017
期刊：
影响因子：
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通讯作者：
K. Ohnishi
中科院分区：
文献类型：
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作者：
K. Ohnishi
癌症干细胞（CSC）或肿瘤起始细胞（TIC）已在多种癌症中被鉴定，并且被定义为具有干细胞样表型的小群体癌细胞。肿瘤干细胞对目前的化疗和放疗具有抵抗力，并具有较高的成瘤能力。CSC可能有助于癌症转移和肿瘤复发，这导致预后不良。因此，CSC的靶向策略对于癌症治疗的进展是极其重要的。然而，CSC本身并没有得到很好的理解。本文综述了CSC研究中应注意的关键点，并考虑了热疗对CSC靶向的有效性。已有研究表明，加热对与CSCs存活相关的细胞内外因子有抑制作用。在这篇综述中，热疗的潜力CSC靶向治疗癌症的关系，这些生存因素进行了讨论。
Cancer stem cells (CSCs) or tumor-initiating cells (TICs) have been identified in a variety of cancers and are defined as a small population of cancer cells that have stem cell-like phenotypes. CSCs are resistant to current chemotherapy and radiotherapy and have high ability of tumorigenesis. It is likely that CSCs contribute to cancer metastases and tumor recurrence, which cause a poor prognosis. Thus, targeting strategy of CSCs is extremely important for advancement of cancer therapies. However, CSC itself is not well understood. This review refers to key points to be noticed in CSC research and considers effectiveness of hyperthermia for CSC-targeting. It has been reported that heating has an inhibitory influence on some extraand intra-cellular factors that are related to the survival of CSCs. In this review, the potentiality of hyperthermia for CSC-targeted cancer therapy is discussed with relation to those survival factors.