FHIT gene therapy prevents tumor development in Fhit-deficient mice
FHIT gene therapy prevents tumor development in Fhit-deficient mice
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DOI：
10.1073/pnas.061020098
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发表时间：
2001-03-13
影响因子：
11.1
通讯作者：
Croce, CM
中科院分区：
文献类型：
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作者：
Dumon, KR;Ishii, H;Croce, CM
肿瘤抑制基因FHIT跨越一个常见的脆性位点，对环境致癌物高度敏感。FHIT失活和表达缺失见于大部分癌前病变和恶性病变。在这项研究中，我们能够抑制肿瘤的发展，通过口服基因转移，使用腺病毒或腺相关病毒载体表达人FHIT基因，在杂合Fhit（+/-）敲除小鼠，这是容易发生肿瘤后致癌物暴露。因此，我们认为FHIT基因治疗可能是一种新的临床方法，不仅在治疗早期癌症，而且在预防人类癌症。
The tumor suppressor gene FHIT spans a common fragile site and is highly susceptible to environmental carcinogens. FHIT inactivation and loss of expression is found in a large fraction of premaligant and malignant lesions. In this study, we were able to inhibit tumor development by oral gene transfer, using adenoviral or adenoassociated viral vectors expressing the human FHIT gene, in heterozygous Fhit(+/-) knockout mice, that are prone to tumor development after carcinogen exposure. We therefore suggest that FHIT gene therapy could be a novel clinical approach not only in treatment of early stages of cancer, but also in prevention of human cancer.