CHARACTERIZATION OF DEFINITY™ ULTRASOUND CONTRAST AGENT AT FREQUENCY RANGE OF 5-15 MHZ
CHARACTERIZATION OF DEFINITY™ ULTRASOUND CONTRAST AGENT AT FREQUENCY RANGE OF 5-15 MHZ
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DOI：
10.1016/j.ultrasmedbio.2010.11.014
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发表时间：
2011-02-01
影响因子：
2.9
通讯作者：
De Jong, Nico
中科院分区：
文献类型：
--
作者：
Faez, Telli;Goertz, David;De Jong, Nico
血管的状态，可以用超声造影剂成像，是动脉粥样硬化进展的指示。用于此目的的首选超声频率在5至15兆赫之间。因此，有必要了解微泡的声学特性，如弹性和粘度，以便能够实现目前用于心前成像频率的脂质包封微泡模型。本文通过对比声学气泡响应的理论模型和实验测量值，在5-15 MHz频率范围内计算了Definity （TM）微气泡的壳体参数、刚度S-p和摩擦S-f。所得参数与先前对SonoVue （TM）和Sonazoid （TM）造影剂的估计一致。然而，在12-28 MHz之间，S-f值高于先前对Definity （TM）的估计。（E-mail: t.faez@erasmusmc.nl） (C) 2011年世界超声医学与生物学联合会。
The status of vasa vasorum, which can be imaged using ultrasound contrast agents, is an indication for the progression of atherosclerosis. The preferred ultrasound frequency for this purpose is between 5 and 15 MHz. Therefore, it is essential to have knowledge about the acoustic properties of microbubbles such as elasticity and viscosity to be able to implement the current models for lipid encapsulated microbubbles developed for frequencies used in precordial imaging. In this study, the shell parameters, stiffness S-p and friction S-f, of Definity (TM) microbubbles have been calculated at frequency range of 5-15 MHz by comparing the theoretical modeling of acoustic bubble response and experimental measurements. Derived parameters are in good agreement with previous estimations on SonoVue (TM) and Sonazoid (TM) contrast agent. However, the value of S-f is higher than previously estimated for Definity (TM) between 12-28 MHz. (E-mail: t.faez@erasmusmc.nl) (C) 2011 World Federation for Ultrasound in Medicine & Biology.