Life stress, the "Kindling" hypothesis, and the recurrence of depression: Considerations from a life stress perspective
Life stress, the "Kindling" hypothesis, and the recurrence of depression: Considerations from a life stress perspective
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DOI：
10.1037/0033-295x.112.2.417
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发表时间：
2005-04-01
影响因子：
5.4
通讯作者：
Harkness, KL
中科院分区：
文献类型：
--
作者：
Monroe, SM;Harkness, KL
重度抑郁症的特点通常是在生命过程中反复发作。然而，与连续复发相比，一生中第一次抑郁症发作通常与主要生活压力的相关性更强。一个关键的理论问题涉及主要生活压力的作用如何从最初的发作到随后的复发发生变化。研究生活压力和抑郁症复发的主要概念框架是“点燃”假说（R. M. Post，1992）。尽管点燃假说有其优点，但对研究文献的回顾揭示了生活压力及其对抑郁症复发的影响的不一致和混乱。作者从生活压力的角度提出了三个主要主题，以解决当前文献中的不一致之处。他们整合这些主题，并用现有数据推断这些想法，以开发一个初步框架来评估相互竞争的解释模型，并指导生活压力和抑郁症复发的研究。
Major depression is frequently characterized by recurrent episodes over the life course. First lifetime episodes of depression, however, are typically more strongly associated with major life stress than are successive recurrences. A key theoretical issue involves how the role of major life stress changes from an initial episode over subsequent recurrences. The primary conceptual framework for research on life stress and recurrence of depression is the "kindling" hypothesis (R. M. Post, 1992). Despite the strengths of the kindling hypothesis, a review of the research literature reveals inconsistencies and confusion about life stress and its implications for the recurrence of depression. Adopting a life stress perspective, the authors introduce 3 major themes that resolve the inconsistencies in the current literature. They integrate these themes and extrapolate the ideas with available data to develop a preliminary framework for evaluating competing explanatory models and to guide research on life stress and the recurrence of depression..